{"title":"成人全身性水痘1例。","authors":"Li Lin, Ruzhi Zhang","doi":"10.2147/CCID.S535689","DOIUrl":null,"url":null,"abstract":"<p><p>Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2167-2172"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417587/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Case of Generalised Varicella in an Adult.\",\"authors\":\"Li Lin, Ruzhi Zhang\",\"doi\":\"10.2147/CCID.S535689\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.</p>\",\"PeriodicalId\":10447,\"journal\":{\"name\":\"Clinical, Cosmetic and Investigational Dermatology\",\"volume\":\"18 \",\"pages\":\"2167-2172\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417587/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical, Cosmetic and Investigational Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CCID.S535689\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S535689","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
