以Isatin衍生物和甘氨酸酯盐酸盐为原料，可见光诱导一锅法合成螺环丙基氧吲哚。

IF 1.6 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chimia Pub Date : 2025-09-10 DOI:10.2533/chimia.2025.639

Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen

{"title":"以Isatin衍生物和甘氨酸酯盐酸盐为原料，可见光诱导一锅法合成螺环丙基氧吲哚。","authors":"Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen","doi":"10.2533/chimia.2025.639","DOIUrl":null,"url":null,"abstract":"An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin derivatives) to afford diastereomeric mixtures of spirocyclopropyl oxoindoles in toluene at room temperature is presented. Spirocyclopropyl oxoindoles are interesting building blocks prevalent in many active pharmaceutical ingredients and in natural products. This protocol is devoid of any metal catalysts or bases.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"639-643"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride.\",\"authors\":\"Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen\",\"doi\":\"10.2533/chimia.2025.639\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin derivatives) to afford diastereomeric mixtures of spirocyclopropyl oxoindoles in toluene at room temperature is presented. Spirocyclopropyl oxoindoles are interesting building blocks prevalent in many active pharmaceutical ingredients and in natural products. This protocol is devoid of any metal catalysts or bases.\",\"PeriodicalId\":9957,\"journal\":{\"name\":\"Chimia\",\"volume\":\"79 9\",\"pages\":\"639-643\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chimia\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2533/chimia.2025.639\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chimia","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2533/chimia.2025.639","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

提出了一种综合的一锅方案，用于原位生成有害的烷基重氮乙酸酯（从甘氨酸酯盐酸盐）及其随后与3-烯基氧吲哚（通过从isatin衍生物的原位Wittig反应生成）在室温下在甲苯中生成螺环丙基氧吲哚的非对映体混合物。螺环丙基氧吲哚是许多活性药物成分和天然产品中普遍存在的有趣的组成部分。本协议不含任何金属催化剂或碱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride.

An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin derivatives) to afford diastereomeric mixtures of spirocyclopropyl oxoindoles in toluene at room temperature is presented. Spirocyclopropyl oxoindoles are interesting building blocks prevalent in many active pharmaceutical ingredients and in natural products. This protocol is devoid of any metal catalysts or bases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chimia 化学-化学综合

CiteScore

1.60

自引率

0.00%

发文量

144

审稿时长

2 months

期刊介绍： CHIMIA, a scientific journal for chemistry in the broadest sense covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.