Angela Ramos-Pinedo, Jose Ignacio de Granda-Orive, Maria Isabel Cristóbal-Fernández, Calos Rábade-Castedo, Elia Pérez-Fernández, Paz Vaquero-Lozano, Maria Inmaculada Gorordo-Unzueta, Lourdes Lázaro-Asegurado, Eva de Higes-Martínez, Juan Antonio Riesco-Miranda, Rosa Mirambeaux-Villalona, Gloria Francisco-Corral, Alejandro Frino-García, Jaime Signes-Costa Miñana, Cristina Villar-Laguna, Ana Maria Cicero-Guerrero, Julio Cesar Vargas-Espinal, Teresa Peña-Miguel, Jacobo Sellares, Carlos Andrés Jiménez-Ruiz
{"title":"Cytisinicline戒烟临床心理护理方案的有效性分析。","authors":"Angela Ramos-Pinedo, Jose Ignacio de Granda-Orive, Maria Isabel Cristóbal-Fernández, Calos Rábade-Castedo, Elia Pérez-Fernández, Paz Vaquero-Lozano, Maria Inmaculada Gorordo-Unzueta, Lourdes Lázaro-Asegurado, Eva de Higes-Martínez, Juan Antonio Riesco-Miranda, Rosa Mirambeaux-Villalona, Gloria Francisco-Corral, Alejandro Frino-García, Jaime Signes-Costa Miñana, Cristina Villar-Laguna, Ana Maria Cicero-Guerrero, Julio Cesar Vargas-Espinal, Teresa Peña-Miguel, Jacobo Sellares, Carlos Andrés Jiménez-Ruiz","doi":"10.1016/j.arbres.2025.08.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The main objective was to analyze the short, medium, and long-term effectiveness of a clinical-psychological care protocol for smoking cessation using cytisinicline. Other secondary objectives were evaluate safety and whether the characteristics of smoking, adherence, and the intensity of craving and withdrawal syndrome at 4th week were associated with effectiveness.</p><p><strong>Methods: </strong>Observational, prospective, multicenter study that includes smokers motivated to quit evaluated in twelve Smoking Cessation Services in Spain.</p><p><strong>Results: </strong>A total of 337 smokers were studied. Effectiveness of cytisinicline was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2%, at 3rd, 6th and 12th month of follow up respectively. The measurement of adherence and the intensity of craving by SRC showed statistically significant association with effectiveness at 24th week, RRadj=2.2 (p<0.001) and RRadj=0.87 (p=0.011) respectively. Common adverse effects (occurring in more than 10% of patients) were: sleep disorders, headaches, dizziness and digestive disorders.</p><p><strong>Conclusions: </strong>The effectiveness of protocol was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2% at 3rd, 6th and 12th months respectively. Subjects who met more than 80% of treatment adherence doubled their chances of success at 6th month. For each point of craving intensity, measured by the SRC, at the end of the pharmacological treatment the chances of success at 6th month were reduced by 13%. Cytisinicline was safe.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of Effectiveness of Clinical Psychological Care Protocol for Smoking Cessation With Cytisinicline.\",\"authors\":\"Angela Ramos-Pinedo, Jose Ignacio de Granda-Orive, Maria Isabel Cristóbal-Fernández, Calos Rábade-Castedo, Elia Pérez-Fernández, Paz Vaquero-Lozano, Maria Inmaculada Gorordo-Unzueta, Lourdes Lázaro-Asegurado, Eva de Higes-Martínez, Juan Antonio Riesco-Miranda, Rosa Mirambeaux-Villalona, Gloria Francisco-Corral, Alejandro Frino-García, Jaime Signes-Costa Miñana, Cristina Villar-Laguna, Ana Maria Cicero-Guerrero, Julio Cesar Vargas-Espinal, Teresa Peña-Miguel, Jacobo Sellares, Carlos Andrés Jiménez-Ruiz\",\"doi\":\"10.1016/j.arbres.2025.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The main objective was to analyze the short, medium, and long-term effectiveness of a clinical-psychological care protocol for smoking cessation using cytisinicline. Other secondary objectives were evaluate safety and whether the characteristics of smoking, adherence, and the intensity of craving and withdrawal syndrome at 4th week were associated with effectiveness.</p><p><strong>Methods: </strong>Observational, prospective, multicenter study that includes smokers motivated to quit evaluated in twelve Smoking Cessation Services in Spain.</p><p><strong>Results: </strong>A total of 337 smokers were studied. Effectiveness of cytisinicline was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2%, at 3rd, 6th and 12th month of follow up respectively. The measurement of adherence and the intensity of craving by SRC showed statistically significant association with effectiveness at 24th week, RRadj=2.2 (p<0.001) and RRadj=0.87 (p=0.011) respectively. Common adverse effects (occurring in more than 10% of patients) were: sleep disorders, headaches, dizziness and digestive disorders.</p><p><strong>Conclusions: </strong>The effectiveness of protocol was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2% at 3rd, 6th and 12th months respectively. Subjects who met more than 80% of treatment adherence doubled their chances of success at 6th month. For each point of craving intensity, measured by the SRC, at the end of the pharmacological treatment the chances of success at 6th month were reduced by 13%. Cytisinicline was safe.</p>\",\"PeriodicalId\":8339,\"journal\":{\"name\":\"Archivos De Bronconeumologia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":9.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos De Bronconeumologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.arbres.2025.08.002\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De Bronconeumologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.arbres.2025.08.002","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Analysis of Effectiveness of Clinical Psychological Care Protocol for Smoking Cessation With Cytisinicline.
Objectives: The main objective was to analyze the short, medium, and long-term effectiveness of a clinical-psychological care protocol for smoking cessation using cytisinicline. Other secondary objectives were evaluate safety and whether the characteristics of smoking, adherence, and the intensity of craving and withdrawal syndrome at 4th week were associated with effectiveness.
Methods: Observational, prospective, multicenter study that includes smokers motivated to quit evaluated in twelve Smoking Cessation Services in Spain.
Results: A total of 337 smokers were studied. Effectiveness of cytisinicline was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2%, at 3rd, 6th and 12th month of follow up respectively. The measurement of adherence and the intensity of craving by SRC showed statistically significant association with effectiveness at 24th week, RRadj=2.2 (p<0.001) and RRadj=0.87 (p=0.011) respectively. Common adverse effects (occurring in more than 10% of patients) were: sleep disorders, headaches, dizziness and digestive disorders.
Conclusions: The effectiveness of protocol was 68% at the end of treatment, but was reduced to 48.7%, 40.9% and 28.2% at 3rd, 6th and 12th months respectively. Subjects who met more than 80% of treatment adherence doubled their chances of success at 6th month. For each point of craving intensity, measured by the SRC, at the end of the pharmacological treatment the chances of success at 6th month were reduced by 13%. Cytisinicline was safe.
期刊介绍：
Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections.
All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.
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