阿克拉霉素在大鼠体内的组织分布。

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-02-01

L Mazzanti, V Scalori, M Mian, M G Alessandrì, L Giovannini

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引用次数: 0

摘要

本研究采用基于组织荧光的方法，研究了阿克拉霉素在大鼠体内的分布。靶器官为肾、肺和胰腺;与阿霉素相比，在心脏中也检测到较弱的荧光，这是由于两种蒽环类药物的定量固定不同。我们的研究结果显示，除肾上腺髓质外，所有检查组织都优先摄取到细胞核，其中仅在细胞质中出现轻微的荧光。

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Aclacinomycin tissue distribution in the rat.

This study was undertaken to investigate aclacinomycin distribution in the rat, using a method based on the histofluorescence of tissues treated in vivo with anthracyclines. The target organs were the kidney, lung and pancreas; a fainter fluorescence was also detected in the heart compared with adriamycin due to a quantitatively different fixing of the two anthracyclines. Our findings revealed a preferential uptake into the cell nucleus in all tissues examined except the adrenal gland medulla where a slight fluorescence appeared only in the cytoplasm.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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