一种简单的水溶性trenn -1,8-萘酰亚胺荧光“开启”PET传感器，用于选择性和可逆检测Cu（II）离子及其在细胞成像中的应用。

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-09-12 DOI:10.1002/asia.70309

Mannanthara Kunhumon Noushija, Sweata Hanson, Deivasigamani Umadevi, Nandita Mishra, Sankarasekaran Shanmugaraju

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引用次数: 0

摘要

以1,8-萘酰酸酐和三（2-氨基乙基）胺（TREN）为原料，通过一锅模拟反应，定量合成了一种新的水溶性1,8-萘酰亚胺荧光团（trenn -nap）。trenn - nap随后被用作荧光“开启”化学传感器，用于检测水中的Cu（II）离子。荧光滴定研究表明，trenn - nap对Cu（II）离子具有显著的选择性和可逆结合亲和力，在微摩尔水平（0.74µM, 0.24 ppm）下荧光发射强度和灵敏度显著增强（开启）。值得注意的是，与其他常见干扰金属阳离子(如Zn(II), Mg(II), Cd(II), Ni(II), Co(II), Ba(II), Al（III), Pb（II）和Ca(II)）类似的滴定研究引起的发射强度变化几乎可以忽略不计，表明它们与trenn - nap的结合较弱。此外，即使在实际水样中，trenn - nap也显示出令人印象深刻的Cu（II）离子传感能力。trenn - nap还被用作乳腺癌（MDA-MB-231）和肺上皮细胞（L929）的生物显像剂。这些结果证实了trenn - nap是一种优秀的荧光“开启”传感器，用于检测水和生物介质中的Cu（II）离子。

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A Simple Water-Soluble TREN-1,8-aphthalimide Fluorescent "Turn-On" PET Sensor for Selective and Reversible Detection of Cu(II) Ion and Application in Cellular Imaging.

A new water-soluble 1,8-naphthalimide fluorophore, TREN-Nap, is synthesized in quantitative yield through a one-pot imidation reaction between 1,8-naphthalic anhydride and tris(2-aminoethyl)amine (TREN). TREN-Nap is then employed as a fluorescent "turn-on" chemosensor for detecting Cu(II) ions in water. The fluorescence titration studies revealed remarkable selectivity and reversible binding affinity of TREN-Nap toward Cu(II) ions, with significant enhancement (turn-on) in fluorescence emission intensity and sensitivity at the micromolar level (0.74 µM, 0.24 ppm). Notably, similar titration studies with other commonly interfering metal cations such as Zn(II), Mg(II), Cd(II), Ni(II), Co(II), Ba(II), Al(III), Pb(II), and Ca(II) caused almost negligible changes in the emission intensity, indicating their weak binding with TREN-Nap. Moreover, TREN-Nap displayed impressive sensing capability for Cu(II) ions even in real water samples. TREN-Nap is further employed as a bioimaging agent in breast cancer (MDA-MB-231) and lung epithelial (L929) cells. These results affirm that TREN-Nap is an excellent fluorescent "turn-on" sensor for Cu(II) ion detection in water and biological media.

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).