封面：slip - pm的发展和最新进展：一个操纵质膜信号传导的化学发生平台（ChemBioChem 16/2025）

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-09-13 DOI:10.1002/cbic.70016

Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji

{"title":"封面：slip - pm的发展和最新进展：一个操纵质膜信号传导的化学发生平台（ChemBioChem 16/2025）","authors":"Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji","doi":"10.1002/cbic.70016","DOIUrl":null,"url":null,"abstract":"<p>SLIPT-PM is a chemogenetic technique that enables the inducible translocation of specific tag-fusion proteins to the plasma membrane (PM) in living cells by using a synthetic self-localizing ligand (SL). This user-friendly method allows researchers to manipulate a wide range of intracellular signaling molecules and pathways with controlled reversibility and repeatability. In 10.1002/cbic.202500327, Shinya Tsukiji and co-workers review the development, key features, current applications, and future challenges of SLIPT-PM as a unique tool in chemical and synthetic biology. Cover art by Hiroko Uchida.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 16","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.70016","citationCount":"0","resultStr":"{\"title\":\"Front Cover: Development and Recent Advances in SLIPT-PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane (ChemBioChem 16/2025)\",\"authors\":\"Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji\",\"doi\":\"10.1002/cbic.70016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>SLIPT-PM is a chemogenetic technique that enables the inducible translocation of specific tag-fusion proteins to the plasma membrane (PM) in living cells by using a synthetic self-localizing ligand (SL). This user-friendly method allows researchers to manipulate a wide range of intracellular signaling molecules and pathways with controlled reversibility and repeatability. In 10.1002/cbic.202500327, Shinya Tsukiji and co-workers review the development, key features, current applications, and future challenges of SLIPT-PM as a unique tool in chemical and synthetic biology. Cover art by Hiroko Uchida.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\"26 16\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.70016\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.70016\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.70016","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

slip -PM是一种化学发生技术，利用合成的自定位配体（SL）将特异性标签融合蛋白诱导易位到活细胞的质膜（PM）上。这种用户友好的方法使研究人员能够操纵广泛的细胞内信号分子和途径，控制可逆性和可重复性。在10.1002 / cbic。202500327， Shinya Tsukiji等人综述了slip - pm作为化学和合成生物学中独特工具的发展、主要特征、当前应用和未来挑战。Hiroko Uchida的封面设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Development and Recent Advances in SLIPT-PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane (ChemBioChem 16/2025)

查看原文本刊更多论文

Front Cover: Development and Recent Advances in SLIPT-PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane (ChemBioChem 16/2025)

SLIPT-PM is a chemogenetic technique that enables the inducible translocation of specific tag-fusion proteins to the plasma membrane (PM) in living cells by using a synthetic self-localizing ligand (SL). This user-friendly method allows researchers to manipulate a wide range of intracellular signaling molecules and pathways with controlled reversibility and repeatability. In 10.1002/cbic.202500327, Shinya Tsukiji and co-workers review the development, key features, current applications, and future challenges of SLIPT-PM as a unique tool in chemical and synthetic biology. Cover art by Hiroko Uchida.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).