Xueying Wang, Yeyu Liu, Yinghan Hu, Yanzhe Huang, Lingyun Zhang, Haizhao Xue, Yongjin J. Zhou, Zongbao K. Zhao
{"title":"封面特写：用于氧化非天然辅因子再生的工程烟酰胺腺嘌呤二核苷酸氧化酶（ChemBioChem 16/2025）","authors":"Xueying Wang, Yeyu Liu, Yinghan Hu, Yanzhe Huang, Lingyun Zhang, Haizhao Xue, Yongjin J. Zhou, Zongbao K. Zhao","doi":"10.1002/cbic.70015","DOIUrl":null,"url":null,"abstract":"<p>Oxidative and reductive reactions are vital processes in cellular metabolism. Like yin and yang in Tai Chi, they are independent and complementary. The non-natural cofactors NCD<sup>+</sup> and NCDH exhibit substantial potential for the bio-orthogonal regulation of redox pathways. To provide sufficient driving force, it is crucial to maintain the NCD<sup>+</sup> and NCDH ratio and homeostasis. In the Research Article 10.1002/cbic.202500254, Xueying Wang, Zongbao K. Zhao, and co-workers explain how they reshaped the NADH-binding pocket of NADH oxidase to accommodate NCDH, thereby facilitating the traceless regeneration of the oxidized cofactor NCD<sup>+</sup> and the selective synthesis of chiral compounds.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 16","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.70015","citationCount":"0","resultStr":"{\"title\":\"Cover Feature: Engineering Nicotinamide Adenine Dinucleotide Oxidase for Regeneration of Oxidized Non-natural Cofactor (ChemBioChem 16/2025)\",\"authors\":\"Xueying Wang, Yeyu Liu, Yinghan Hu, Yanzhe Huang, Lingyun Zhang, Haizhao Xue, Yongjin J. Zhou, Zongbao K. Zhao\",\"doi\":\"10.1002/cbic.70015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Oxidative and reductive reactions are vital processes in cellular metabolism. Like yin and yang in Tai Chi, they are independent and complementary. The non-natural cofactors NCD<sup>+</sup> and NCDH exhibit substantial potential for the bio-orthogonal regulation of redox pathways. To provide sufficient driving force, it is crucial to maintain the NCD<sup>+</sup> and NCDH ratio and homeostasis. In the Research Article 10.1002/cbic.202500254, Xueying Wang, Zongbao K. Zhao, and co-workers explain how they reshaped the NADH-binding pocket of NADH oxidase to accommodate NCDH, thereby facilitating the traceless regeneration of the oxidized cofactor NCD<sup>+</sup> and the selective synthesis of chiral compounds.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\"26 16\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.70015\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.70015\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.70015","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Cover Feature: Engineering Nicotinamide Adenine Dinucleotide Oxidase for Regeneration of Oxidized Non-natural Cofactor (ChemBioChem 16/2025)
Oxidative and reductive reactions are vital processes in cellular metabolism. Like yin and yang in Tai Chi, they are independent and complementary. The non-natural cofactors NCD+ and NCDH exhibit substantial potential for the bio-orthogonal regulation of redox pathways. To provide sufficient driving force, it is crucial to maintain the NCD+ and NCDH ratio and homeostasis. In the Research Article 10.1002/cbic.202500254, Xueying Wang, Zongbao K. Zhao, and co-workers explain how they reshaped the NADH-binding pocket of NADH oxidase to accommodate NCDH, thereby facilitating the traceless regeneration of the oxidized cofactor NCD+ and the selective synthesis of chiral compounds.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
