Doratha A. Byrd, Maria F. Gomez, Stephanie R. Hogue, Jessica R. Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G. Wolf, Yunhu Wan, Andrew Warner, Belynda Hicks, Casey Dagnall, Kristine Jones, Youngchul Kim, Jin Xu, Jianxin Shi, Rashmi Sinha, Emily Vogtmann
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引用次数: 0
摘要
目的肠道微生物群和胆汁酸（BAs）可能影响结直肠癌（CRC）的发展和差异。我们进行了一项巢式病例对照研究，在先前进行的平均风险妇女地区海军/陆军医疗中心研究（CONCeRN）中进行的多中心结肠镜检查结直肠肿瘤筛查中，结肠组织微生物群和循环BAs与结直肠腺瘤患病率之间的关系。方法将143例腺瘤患者与279例非腺瘤患者进行配对。利用16S rRNA基因测序，我们评估了α和β多样性、分类丰度和共丰度群（CAGs）。分析空腹血清中13种原发性和继发性BAs。结果口腔源性卟啉单胞菌的存在与腺瘤呈正相关（优势比[OR]和95%可信区间[CI] = 2.50 [1.18, 5.30]; p = 0.02）。种族和研究中心解释了beta多样性矩阵中统计上显著的变异百分比。ba通常与腺瘤呈正相关，尽管这些结果没有统计学意义。总的来说，我们的研究结果表明，结肠组织微生物组可能因种族和地理而异，某些口腔起源的细菌可能与腺瘤呈正相关。
Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average-Risk Women
Objective
The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case–control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi-center Colorectal Neoplasia Screening with Colonoscopy in Average-Risk Women Regional Navy/Army Medical Centers study (CONCeRN).
Methods
We individually matched 143 women with adenoma to 279 without adenoma. Using 16S rRNA gene sequencing, we assessed alpha and beta diversity, taxonomic abundance, and co-abundance groups (CAGs). Fasting serum was analyzed for 13 primary and secondary BAs.
Results
The presence of oral-originating Porphyromonas was positively associated with adenomas (odds ratio [OR] and 95% confidence interval [CI] = 2.50 [1.18, 5.30]; p = 0.02). Race and study center explained statistically significant percentages of variation in the beta diversity matrices. BAs were generally positively associated with adenomas, though these results were not statistically significant.
Discussion
Overall, our findings suggest the colon tissue microbiome may differ by race and geography, and that certain oral-originating bacteria may be positively associated with adenomas.
期刊介绍：
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas:
Clinical Cancer Research
Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations
Cancer Biology:
Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery.
Cancer Prevention:
Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach.
Bioinformatics:
Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers.
Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
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