Lathewdeipor Shadap, Charlestine Soh, Smarling Suting, Mayuri Bhattacharyya, Baphilinia Jones Mylliemngap, Suktilang Majaw, Werner Kaminsky, Kenneth Umdor, Cheerfulman Masharing, Badaker M. Laloo, Barisha Wahlang, Matbiangthew Shadap, Evergreen K. Rymmai
{"title":"含氮供体配体的钌配合物：合成及其细胞毒性潜力的研究","authors":"Lathewdeipor Shadap, Charlestine Soh, Smarling Suting, Mayuri Bhattacharyya, Baphilinia Jones Mylliemngap, Suktilang Majaw, Werner Kaminsky, Kenneth Umdor, Cheerfulman Masharing, Badaker M. Laloo, Barisha Wahlang, Matbiangthew Shadap, Evergreen K. Rymmai","doi":"10.1007/s11243-025-00654-6","DOIUrl":null,"url":null,"abstract":"<div><p>Complexes (<b>1</b>–<b>3</b>) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η<sup>6</sup>-<i>p</i>-cymene)(<i>μ</i>-Cl)Cl]<sub>2</sub> and ligands <b>L1</b>, <b>L2</b> and <b>L3</b>. Upon reacting the complexes <b>1</b>–<b>3</b> with sodium azide, azido complexes <b>4</b>–<b>6</b> were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand <b>L2</b> was found to have lowest IC<sub>50</sub> value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.</p><h3>Graphical Abstract</h3><p>\nHalf-sandwich ruthenium complexes <b>1</b>–<b>3</b> were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes <b>4</b>–<b>6</b>. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand <b>L2</b> has the highest anti-cancer activity amongst the others studied.</p><div><figure><div><div><picture><source><img></source></picture></div><div><p>Azido Ruthenium Complex <b>4</b></p></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 5","pages":"753 - 762"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ruthenium complexes comprising nitrogen donor ligands: synthesis and investigation of their cytotoxicity potential\",\"authors\":\"Lathewdeipor Shadap, Charlestine Soh, Smarling Suting, Mayuri Bhattacharyya, Baphilinia Jones Mylliemngap, Suktilang Majaw, Werner Kaminsky, Kenneth Umdor, Cheerfulman Masharing, Badaker M. Laloo, Barisha Wahlang, Matbiangthew Shadap, Evergreen K. Rymmai\",\"doi\":\"10.1007/s11243-025-00654-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Complexes (<b>1</b>–<b>3</b>) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η<sup>6</sup>-<i>p</i>-cymene)(<i>μ</i>-Cl)Cl]<sub>2</sub> and ligands <b>L1</b>, <b>L2</b> and <b>L3</b>. Upon reacting the complexes <b>1</b>–<b>3</b> with sodium azide, azido complexes <b>4</b>–<b>6</b> were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand <b>L2</b> was found to have lowest IC<sub>50</sub> value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.</p><h3>Graphical Abstract</h3><p>\\nHalf-sandwich ruthenium complexes <b>1</b>–<b>3</b> were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes <b>4</b>–<b>6</b>. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand <b>L2</b> has the highest anti-cancer activity amongst the others studied.</p><div><figure><div><div><picture><source><img></source></picture></div><div><p>Azido Ruthenium Complex <b>4</b></p></div></div></figure></div></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"50 5\",\"pages\":\"753 - 762\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-025-00654-6\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-025-00654-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Ruthenium complexes comprising nitrogen donor ligands: synthesis and investigation of their cytotoxicity potential
Complexes (1–3) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η6-p-cymene)(μ-Cl)Cl]2 and ligands L1, L2 and L3. Upon reacting the complexes 1–3 with sodium azide, azido complexes 4–6 were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand L2 was found to have lowest IC50 value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.
Graphical Abstract
Half-sandwich ruthenium complexes 1–3 were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes 4–6. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand L2 has the highest anti-cancer activity amongst the others studied.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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