Haotian Cha, Fariba Malekpour Galogahi, Quang Thang Trinh, Sharda Yadav, Jun Zhang, Hongjie An, Qin Li and Nam-Trung Nguyen
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A theoretical force model was first established to describe asymmetrical spreading, governed by Laplace pressure gradients and geometric curvature. Numerical simulations based on energy-minimization principles further elucidated wetting behaviour on structured surfaces. Concurrently, experimental validation confirmed three distinct flow regimes—pinned, unidirectional, and bidirectional—controlled by plasma-induced wettability modulation and applied mechanical strain. Stretching the channels along orthogonal axes led to programmable switching of flow states and geometry-sensitive pinning thresholds. We further integrated a hydrogel film as a sweat-acquisition interface and demonstrated sustained unidirectional transport under physiologically relevant inflow. This proof-of-concept validation complements the fundamental findings and highlights the translational potential of our open-channel platform as a simple, tuneable, and pumpless approach for wearable diagnostics, adaptive liquid routing, and flexible microfluidic circuitry.</p>","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":" 21","pages":" 5460-5472"},"PeriodicalIF":5.4000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Micro elastofluidic liquid diode for programmable unidirectional flow control\",\"authors\":\"Haotian Cha, Fariba Malekpour Galogahi, Quang Thang Trinh, Sharda Yadav, Jun Zhang, Hongjie An, Qin Li and Nam-Trung Nguyen\",\"doi\":\"10.1039/D5LC00438A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Controllable liquid transport is essential for fluid regulation in wearable biosensing platforms. Particularly, unidirectional flow offers a passive, geometry-dependent strategy to direct liquid movement without external actuation. However, most previous studies have focused solely on achieving unidirectional flow, with limited exploration of real-time tunability or reconfigurability. Here, we present a tuneable open-channel microfluidic platform featuring a chevron–ratchet geometry that enables passive and reversible liquid diode behaviour. Flow directionality and velocity are dynamically modulated through surface wettability tuning and mechanical stretching. A theoretical force model was first established to describe asymmetrical spreading, governed by Laplace pressure gradients and geometric curvature. Numerical simulations based on energy-minimization principles further elucidated wetting behaviour on structured surfaces. Concurrently, experimental validation confirmed three distinct flow regimes—pinned, unidirectional, and bidirectional—controlled by plasma-induced wettability modulation and applied mechanical strain. Stretching the channels along orthogonal axes led to programmable switching of flow states and geometry-sensitive pinning thresholds. We further integrated a hydrogel film as a sweat-acquisition interface and demonstrated sustained unidirectional transport under physiologically relevant inflow. This proof-of-concept validation complements the fundamental findings and highlights the translational potential of our open-channel platform as a simple, tuneable, and pumpless approach for wearable diagnostics, adaptive liquid routing, and flexible microfluidic circuitry.</p>\",\"PeriodicalId\":85,\"journal\":{\"name\":\"Lab on a Chip\",\"volume\":\" 21\",\"pages\":\" 5460-5472\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lab on a Chip\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/lc/d5lc00438a\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab on a Chip","FirstCategoryId":"5","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/lc/d5lc00438a","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Micro elastofluidic liquid diode for programmable unidirectional flow control
Controllable liquid transport is essential for fluid regulation in wearable biosensing platforms. Particularly, unidirectional flow offers a passive, geometry-dependent strategy to direct liquid movement without external actuation. However, most previous studies have focused solely on achieving unidirectional flow, with limited exploration of real-time tunability or reconfigurability. Here, we present a tuneable open-channel microfluidic platform featuring a chevron–ratchet geometry that enables passive and reversible liquid diode behaviour. Flow directionality and velocity are dynamically modulated through surface wettability tuning and mechanical stretching. A theoretical force model was first established to describe asymmetrical spreading, governed by Laplace pressure gradients and geometric curvature. Numerical simulations based on energy-minimization principles further elucidated wetting behaviour on structured surfaces. Concurrently, experimental validation confirmed three distinct flow regimes—pinned, unidirectional, and bidirectional—controlled by plasma-induced wettability modulation and applied mechanical strain. Stretching the channels along orthogonal axes led to programmable switching of flow states and geometry-sensitive pinning thresholds. We further integrated a hydrogel film as a sweat-acquisition interface and demonstrated sustained unidirectional transport under physiologically relevant inflow. This proof-of-concept validation complements the fundamental findings and highlights the translational potential of our open-channel platform as a simple, tuneable, and pumpless approach for wearable diagnostics, adaptive liquid routing, and flexible microfluidic circuitry.
期刊介绍:
Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.