Naghmeh Ziaie, Mohammad Barary, Mostafa Javanian, Soheil Bakhshinasab, Soheil Ebrahimpour
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Commentary on “The Association of Circulating Bone Morphogenetic Protein 9 and Arterial Stiffness in Hypertensive Patients”
Dear Editor,
In summary, BMP-9 shows biologic plausibility and modest discriminative power for arterial stiffness, but residual confounding, single-time-point measurement, and limited external validity temper enthusiasm for immediate clinical adoption. Future longitudinal, population-based studies incorporating richer lifestyle, pharmacologic, and inflammatory data, and reporting decision-analytic metrics, are essential to define the incremental value of BMP-9-guided risk stratification in hypertension care.
Majid Khalilizad: investigation, writing - original draft preparation. Mehdi Tavassoli: investigation, writing - original draft preparation. Mohammad Barary: investigation, writing - original draft preparation, writing - review and editing. Mostafa Javanian: investigation, writing - original draft preparation. Soheil Ebrahimpour: investigation, supervision, writing - original draft preparation. All authors contributed significantly to the work and approved the final version of the manuscript. Their contributions align with the latest guidelines of the International Committee of Medical Journal Editors.
期刊介绍：
The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.
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