Romain Alfieri, Bernard Duysinx, Renaud Louis, Vincent Heinen
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引用次数: 0
摘要
严重肺气肿损害慢性阻塞性肺疾病(COPD)患者的肺功能和生活质量。尽管优化了药物治疗和康复,但一些患者需要肺减容干预(内窥镜或手术)。本研究评估了在CHU医院肺气肿诊所治疗的患者一年的预后。这项回顾性观察和纵向单中心研究纳入了2021年至2023年多学科会议上讨论的65例患者。患者被分为两组:支气管镜下使用支气管内瓣膜(EBV)进行肺减容(BLVR)治疗(n = 24),肺减容手术(LVRS)或转介肺移植(LTx);和未治疗组(n = 41)。在基线(T0)和一年后(T1)比较临床和功能参数。治疗一年后,患者1秒用力呼气量(FEV1: + 8.19%, p = 0.0051)、6分钟步行测试距离(+54.6 m, p = 0.018)和COPD评估测试(CAT评分:-5.3分,p = 0.0017)均有显著改善。根据严格的标准和多学科咨询,对肺气肿进行先进的干预可以改善选定患者的呼吸功能、步行距离和生活质量。
[One-year clinical results of the Multidisciplinary Consultation at the Emphysema Clinic of CHU Liege].
Severe emphysema impairs lung function and quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD). Despite optimized medical treatment and rehabilitation, some patients require lung volume reduction interventions (endoscopic or surgical). This study evaluates one-year outcomes of patients managed at the Emphysema Clinic of CHU Liège. This retrospective observational and longitudinal single-center study included 65 patients discussed in multidisciplinary meetings between 2021 and 2023. Patients were divided into two groups: treated (n = 24) with bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBV), lung volume reduction surgery (LVRS), or referred for lung transplantation (LTx); and non-treated (n = 41). Clinical and functional parameters were compared at baseline (T0) and after one year (T1). At one year, treated patients showed a significant improvement in forced expiratory volume in 1 second (FEV1 : +8.19 %, p = 0.0051), six-minute walk test distance (+54.6 m, p = 0.018), and COPD Assesment Test (CAT score : -5.3 points, p = 0.0017). Advanced interventions for emphysema improve respiratory function, walking distance and quality of life in selected patients based on strict criteria and multidisciplinary consultation.