乙酰胆碱和毒蕈碱受体在变应性鼻炎中的作用:机制、临床观察和未来方向。

IF 4.6 2区 医学 Q1 ALLERGY
Xian Li, Yuan Zhang, Luo Zhang
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引用次数: 0

摘要

回顾目的:变应性鼻炎(AR)是一种非常常见和令人困扰的疾病,严重影响患者的生活质量。我们迫切需要了解这种疾病背后的免疫病理因素。乙酰胆碱是一种神经递质,已成为AR发病机制的关键调节因子之一。近期发现:胆碱能递质及其毒蕈碱受体的升高是AR发病过程中鼻超敏反应和鼻分泌过多的主要驱动因素。除了诱导广泛的粘液分泌外,乙酰胆碱在免疫调节和气道重塑中的相关研究数据仍然是碎片化的。与AR相关的乙酰胆碱信号通路的免疫病理机制可能为临床医生提供控制患者症状的药物选择的新见解。我们重点介绍乙酰胆碱在AR发病机制中的作用,以及鼻内抗胆碱能药物治疗AR的临床试验结果,希望为患者的治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions.

Purpose of review: Allergic rhinitis (AR) is a very common and troubling disorder that severely affects patients' quality of life. There is an urgent need to understand the immunopathologic factors behind the disease. Acetylcholine is a neurotransmitter that has emerged as one of the critical regulators of AR pathogenesis.

Recent findings: The elevation of cholinergic transmitters and their muscarinic receptors is a major driver of nasal hypersensitivity and excessive nasal secretion in AR pathogenesis. In addition to inducing extensive mucus secretions, the relevant research data for acetylcholine in immune regulation and airway remodeling remain fragmented. The immunopathological mechanisms underlying acetylcholine signaling pathways associated with AR may provide clinical practitioners with novel insights for medication selection in controlling patients' symptoms. We highlight the roles of acetylcholine in AR pathogenesis and the findings of clinical trials on intranasal anticholinergics use in AR, and hope to provide a reference for patients' management.

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来源期刊
CiteScore
11.20
自引率
1.80%
发文量
21
审稿时长
6-12 weeks
期刊介绍: The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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