{"title":"乙酰胆碱和毒蕈碱受体在变应性鼻炎中的作用:机制、临床观察和未来方向。","authors":"Xian Li, Yuan Zhang, Luo Zhang","doi":"10.1007/s11882-025-01221-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Allergic rhinitis (AR) is a very common and troubling disorder that severely affects patients' quality of life. There is an urgent need to understand the immunopathologic factors behind the disease. Acetylcholine is a neurotransmitter that has emerged as one of the critical regulators of AR pathogenesis.</p><p><strong>Recent findings: </strong>The elevation of cholinergic transmitters and their muscarinic receptors is a major driver of nasal hypersensitivity and excessive nasal secretion in AR pathogenesis. In addition to inducing extensive mucus secretions, the relevant research data for acetylcholine in immune regulation and airway remodeling remain fragmented. The immunopathological mechanisms underlying acetylcholine signaling pathways associated with AR may provide clinical practitioners with novel insights for medication selection in controlling patients' symptoms. We highlight the roles of acetylcholine in AR pathogenesis and the findings of clinical trials on intranasal anticholinergics use in AR, and hope to provide a reference for patients' management.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"37"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions.\",\"authors\":\"Xian Li, Yuan Zhang, Luo Zhang\",\"doi\":\"10.1007/s11882-025-01221-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>Allergic rhinitis (AR) is a very common and troubling disorder that severely affects patients' quality of life. There is an urgent need to understand the immunopathologic factors behind the disease. Acetylcholine is a neurotransmitter that has emerged as one of the critical regulators of AR pathogenesis.</p><p><strong>Recent findings: </strong>The elevation of cholinergic transmitters and their muscarinic receptors is a major driver of nasal hypersensitivity and excessive nasal secretion in AR pathogenesis. In addition to inducing extensive mucus secretions, the relevant research data for acetylcholine in immune regulation and airway remodeling remain fragmented. The immunopathological mechanisms underlying acetylcholine signaling pathways associated with AR may provide clinical practitioners with novel insights for medication selection in controlling patients' symptoms. We highlight the roles of acetylcholine in AR pathogenesis and the findings of clinical trials on intranasal anticholinergics use in AR, and hope to provide a reference for patients' management.</p>\",\"PeriodicalId\":55198,\"journal\":{\"name\":\"Current Allergy and Asthma Reports\",\"volume\":\"25 1\",\"pages\":\"37\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Allergy and Asthma Reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11882-025-01221-w\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Allergy and Asthma Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11882-025-01221-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions.
Purpose of review: Allergic rhinitis (AR) is a very common and troubling disorder that severely affects patients' quality of life. There is an urgent need to understand the immunopathologic factors behind the disease. Acetylcholine is a neurotransmitter that has emerged as one of the critical regulators of AR pathogenesis.
Recent findings: The elevation of cholinergic transmitters and their muscarinic receptors is a major driver of nasal hypersensitivity and excessive nasal secretion in AR pathogenesis. In addition to inducing extensive mucus secretions, the relevant research data for acetylcholine in immune regulation and airway remodeling remain fragmented. The immunopathological mechanisms underlying acetylcholine signaling pathways associated with AR may provide clinical practitioners with novel insights for medication selection in controlling patients' symptoms. We highlight the roles of acetylcholine in AR pathogenesis and the findings of clinical trials on intranasal anticholinergics use in AR, and hope to provide a reference for patients' management.
期刊介绍:
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.