{"title":"植物纳米囊泡促进间充质干细胞治疗：脊髓损伤的新一代先进治疗药物产品。","authors":"Zhe Wang, Wenwen Deng, Qingtong Yu, Jiangnan Yu, Ximing Xu","doi":"10.1177/19373341251372972","DOIUrl":null,"url":null,"abstract":"<p><p>The poor prognosis constitutes a significant difficulty for spinal cord injury (SCI) individuals. Although mesenchymal stem cells (MSCs) hold promises as advanced therapy medicinal products (ATMPs) for SCI patients, challenges such as Good Manufacturing Practice-compliant manufacturing, cellular senescence, and limited therapeutic efficacy continue to hinder their clinical translation. Recent advances have identified botanical nanovesicles (BNs) as potent bioactive mediators capable of \"priming\" MSCs to self-rejuvenate, augment paracrine effect, and establish inflammatory tolerance. In this review, we introduce the physicochemical properties of BNs and systematically explore their synergistic relationship with MSCs in regenerative medicine. By integrating BNs with MSC, BNs-empowered MSCs (Be-MSCs) represent next-generation ATMPs. This innovative strategy addresses the limitations of conventional MSC therapies and offers a scalable, nonimmunogenic solution with significant potential for clinical application in SCI.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Botanical Nanovesicles Boost Mesenchymal Stem Cell Therapy: Next-Gen Advanced Therapy Medicinal Products for Spinal Cord Injury.\",\"authors\":\"Zhe Wang, Wenwen Deng, Qingtong Yu, Jiangnan Yu, Ximing Xu\",\"doi\":\"10.1177/19373341251372972\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The poor prognosis constitutes a significant difficulty for spinal cord injury (SCI) individuals. Although mesenchymal stem cells (MSCs) hold promises as advanced therapy medicinal products (ATMPs) for SCI patients, challenges such as Good Manufacturing Practice-compliant manufacturing, cellular senescence, and limited therapeutic efficacy continue to hinder their clinical translation. Recent advances have identified botanical nanovesicles (BNs) as potent bioactive mediators capable of \\\"priming\\\" MSCs to self-rejuvenate, augment paracrine effect, and establish inflammatory tolerance. In this review, we introduce the physicochemical properties of BNs and systematically explore their synergistic relationship with MSCs in regenerative medicine. By integrating BNs with MSC, BNs-empowered MSCs (Be-MSCs) represent next-generation ATMPs. This innovative strategy addresses the limitations of conventional MSC therapies and offers a scalable, nonimmunogenic solution with significant potential for clinical application in SCI.</p>\",\"PeriodicalId\":23134,\"journal\":{\"name\":\"Tissue Engineering. Part B, Reviews\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tissue Engineering. Part B, Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/19373341251372972\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tissue Engineering. Part B, Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/19373341251372972","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
The poor prognosis constitutes a significant difficulty for spinal cord injury (SCI) individuals. Although mesenchymal stem cells (MSCs) hold promises as advanced therapy medicinal products (ATMPs) for SCI patients, challenges such as Good Manufacturing Practice-compliant manufacturing, cellular senescence, and limited therapeutic efficacy continue to hinder their clinical translation. Recent advances have identified botanical nanovesicles (BNs) as potent bioactive mediators capable of "priming" MSCs to self-rejuvenate, augment paracrine effect, and establish inflammatory tolerance. In this review, we introduce the physicochemical properties of BNs and systematically explore their synergistic relationship with MSCs in regenerative medicine. By integrating BNs with MSC, BNs-empowered MSCs (Be-MSCs) represent next-generation ATMPs. This innovative strategy addresses the limitations of conventional MSC therapies and offers a scalable, nonimmunogenic solution with significant potential for clinical application in SCI.
期刊介绍：
Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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