{"title":"不同级别圆锥角膜患者前节参数的日变化。","authors":"Jinxuan Xiahou, Rui Ning, Shuoyu Xu, Kexin Li, Ingemar Gustafsson, Yiran Wang, Xinning Yang, Xingtao Zhou, Jinhai Huang","doi":"10.1167/tvst.14.9.15","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease.</p><p><strong>Methods: </strong>A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany). The eyes were graded as mild, moderate, or severe KC according to the Topographical Keratoconus Classification system. The Kolmogorov-Smirnov test was applied to assess the normality of the data distribution. Diurnal variations in these parameters were analyzed using repeated-measures analysis of variance.</p><p><strong>Results: </strong>Significant diurnal variations were found in central corneal thickness (CCT) and thinnest corneal thickness (TCT) in patients with KC. The mean amplitude of change between 08:30 and 11:30 was 5.73 µm for CCT and 5.83 µm for TCT. These variations were significant in mild to moderate KC but not in severe KC. In addition, corneal volume showed significant diurnal variations in all KC, while keratometry and anterior chamber depth did not.</p><p><strong>Conclusions: </strong>The study highlights that significant diurnal variation in corneal and anterior chamber parameters, specifically CCT and TCT, is prominent in patients with KC, especially those with mild and moderate disease severity.</p><p><strong>Translational relevance: </strong>The results of the diurnal variation patterns of anterior segment parameters in patients with KC contribute to the evaluation of surgical safety and the assessment of follow-up progression. These research findings provide a basis for clinicians to better manage the condition of patients with KC.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 9","pages":"15"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439498/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diurnal Variations in Anterior Segment Parameters in Different Grades of Patients With Keratoconus.\",\"authors\":\"Jinxuan Xiahou, Rui Ning, Shuoyu Xu, Kexin Li, Ingemar Gustafsson, Yiran Wang, Xinning Yang, Xingtao Zhou, Jinhai Huang\",\"doi\":\"10.1167/tvst.14.9.15\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease.</p><p><strong>Methods: </strong>A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany). The eyes were graded as mild, moderate, or severe KC according to the Topographical Keratoconus Classification system. The Kolmogorov-Smirnov test was applied to assess the normality of the data distribution. Diurnal variations in these parameters were analyzed using repeated-measures analysis of variance.</p><p><strong>Results: </strong>Significant diurnal variations were found in central corneal thickness (CCT) and thinnest corneal thickness (TCT) in patients with KC. The mean amplitude of change between 08:30 and 11:30 was 5.73 µm for CCT and 5.83 µm for TCT. These variations were significant in mild to moderate KC but not in severe KC. In addition, corneal volume showed significant diurnal variations in all KC, while keratometry and anterior chamber depth did not.</p><p><strong>Conclusions: </strong>The study highlights that significant diurnal variation in corneal and anterior chamber parameters, specifically CCT and TCT, is prominent in patients with KC, especially those with mild and moderate disease severity.</p><p><strong>Translational relevance: </strong>The results of the diurnal variation patterns of anterior segment parameters in patients with KC contribute to the evaluation of surgical safety and the assessment of follow-up progression. These research findings provide a basis for clinicians to better manage the condition of patients with KC.</p>\",\"PeriodicalId\":23322,\"journal\":{\"name\":\"Translational Vision Science & Technology\",\"volume\":\"14 9\",\"pages\":\"15\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439498/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Vision Science & Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1167/tvst.14.9.15\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.9.15","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Diurnal Variations in Anterior Segment Parameters in Different Grades of Patients With Keratoconus.
Purpose: This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease.
Methods: A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany). The eyes were graded as mild, moderate, or severe KC according to the Topographical Keratoconus Classification system. The Kolmogorov-Smirnov test was applied to assess the normality of the data distribution. Diurnal variations in these parameters were analyzed using repeated-measures analysis of variance.
Results: Significant diurnal variations were found in central corneal thickness (CCT) and thinnest corneal thickness (TCT) in patients with KC. The mean amplitude of change between 08:30 and 11:30 was 5.73 µm for CCT and 5.83 µm for TCT. These variations were significant in mild to moderate KC but not in severe KC. In addition, corneal volume showed significant diurnal variations in all KC, while keratometry and anterior chamber depth did not.
Conclusions: The study highlights that significant diurnal variation in corneal and anterior chamber parameters, specifically CCT and TCT, is prominent in patients with KC, especially those with mild and moderate disease severity.
Translational relevance: The results of the diurnal variation patterns of anterior segment parameters in patients with KC contribute to the evaluation of surgical safety and the assessment of follow-up progression. These research findings provide a basis for clinicians to better manage the condition of patients with KC.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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