Caseazins R-Y，来自库氏干酪菌的细胞毒性podocarpane二萜。

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-09-08 DOI:10.1016/j.phytochem.2025.114675

Xue-Wen Wu , Qiong Wei , Xia Pu , Chun-Mei Cha , Rui Li , Yin-Qiao Huang , Rui-Han Zhang , Xiao-Li Li , Hong-Liang Li , Wei-Lie Xiao

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引用次数: 0

摘要

本研究从库尔库尔科Casearia kurzii （Flacourtiaceae）的树枝和叶片中分离得到8个未描述的化合物caseazins R-Y（1-8）。它们的结构通过广泛的光谱分析、核磁共振方法、x射线衍射分析和ECD计算得以阐明。化合物1被表征为罕见的2,3-seco碳碳骨架。而化合物8是一种高氧的聚二萜二聚体，在C-2和C-11′之间有一个氧桥。生物实验表明，二萜二聚体8对结直肠癌细胞SW-620具有潜在的细胞毒活性，IC50值为7.29±0.10 μM。此外，化合物8对结直肠癌靶点PI3KαH1047R具有中等抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Caseazins R−Y, cytotoxic podocarpane diterpenoids from Casearia kurzii

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Caseazins R−Y, cytotoxic podocarpane diterpenoids from Casearia kurzii

In the present study, eight undescribed compounds, namely caseazins R−Y (1−8) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae). Their structures were elucidated by extensive spectroscopic analysis, nuclear magnetic resonance methods, X-ray diffraction analysis, and ECD calculations. Compound 1 was characterized as a rare 2,3-seco podocarpane carbon skeleton. While compound 8 was a highly oxygenated podocarpane diterpenoid dimer with an oxygen bridge between C-2 and C-11'. In bioassay, the diterpenoid dimer 8 showed potential cytotoxic activity against colorectal cancer cells (SW-620) with IC₅₀ value of 7.29 ± 0.10 μM. Besides, compound 8 exhibited moderate inhibitory activity against colorectal cancer target PI3Kα^H1047R.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.