Anila A Chaudhary, Chandra Srinivasan, Katsuhide Maeda, Aaron G DeWitt, Catherine Montgomery, Radhika Rastogi, Matthew J O'Connor, Jonathan J Edwards, Humera Ahmed, Kimberly Y Lin, Joseph W Rossano, Carol Wittlieb-Weber, Jonathan B Edelson
{"title":"心脏再同步化治疗辅助心室辅助装置外植于婴儿心肌病和左束支传导阻滞。","authors":"Anila A Chaudhary, Chandra Srinivasan, Katsuhide Maeda, Aaron G DeWitt, Catherine Montgomery, Radhika Rastogi, Matthew J O'Connor, Jonathan J Edwards, Humera Ahmed, Kimberly Y Lin, Joseph W Rossano, Carol Wittlieb-Weber, Jonathan B Edelson","doi":"10.1007/s00246-025-04022-0","DOIUrl":null,"url":null,"abstract":"<p><p>Two previously healthy infants presented with severely dilated left ventricles (LV) and severely diminished left ventricular function. Their initial ECGs demonstrated a left bundle branch block (LBBB) with evidence of dyskinetic septal wall motion on serial echocardiograms. Both were supported with a Berlin Heart EXCOR left ventricular assist device (LVAD). Serial LVAD turn down trials demonstrated improvement in LV function, though with ongoing pronounced septal dyskinesis due to the LBBB. Both underwent successful LVAD explantation with simultaneous epicardial lead placement for biventricular cardiac resynchronization therapy (CRT) given the ongoing dyssynchrony. LVAD explantation in this age group is rare. These cases highlight CRT as a strategy which may aid in the successful explant of ventricular assist devices in select patients who have LBBB and evidence of dyssynchrony by echocardiogram.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardiac Resynchronization Therapy to Aid Ventricular Assist Device Explantation in Infants with Cardiomyopathy and Left Bundle Branch Block.\",\"authors\":\"Anila A Chaudhary, Chandra Srinivasan, Katsuhide Maeda, Aaron G DeWitt, Catherine Montgomery, Radhika Rastogi, Matthew J O'Connor, Jonathan J Edwards, Humera Ahmed, Kimberly Y Lin, Joseph W Rossano, Carol Wittlieb-Weber, Jonathan B Edelson\",\"doi\":\"10.1007/s00246-025-04022-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two previously healthy infants presented with severely dilated left ventricles (LV) and severely diminished left ventricular function. Their initial ECGs demonstrated a left bundle branch block (LBBB) with evidence of dyskinetic septal wall motion on serial echocardiograms. Both were supported with a Berlin Heart EXCOR left ventricular assist device (LVAD). Serial LVAD turn down trials demonstrated improvement in LV function, though with ongoing pronounced septal dyskinesis due to the LBBB. Both underwent successful LVAD explantation with simultaneous epicardial lead placement for biventricular cardiac resynchronization therapy (CRT) given the ongoing dyssynchrony. LVAD explantation in this age group is rare. These cases highlight CRT as a strategy which may aid in the successful explant of ventricular assist devices in select patients who have LBBB and evidence of dyssynchrony by echocardiogram.</p>\",\"PeriodicalId\":19814,\"journal\":{\"name\":\"Pediatric Cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00246-025-04022-0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00246-025-04022-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Cardiac Resynchronization Therapy to Aid Ventricular Assist Device Explantation in Infants with Cardiomyopathy and Left Bundle Branch Block.
Two previously healthy infants presented with severely dilated left ventricles (LV) and severely diminished left ventricular function. Their initial ECGs demonstrated a left bundle branch block (LBBB) with evidence of dyskinetic septal wall motion on serial echocardiograms. Both were supported with a Berlin Heart EXCOR left ventricular assist device (LVAD). Serial LVAD turn down trials demonstrated improvement in LV function, though with ongoing pronounced septal dyskinesis due to the LBBB. Both underwent successful LVAD explantation with simultaneous epicardial lead placement for biventricular cardiac resynchronization therapy (CRT) given the ongoing dyssynchrony. LVAD explantation in this age group is rare. These cases highlight CRT as a strategy which may aid in the successful explant of ventricular assist devices in select patients who have LBBB and evidence of dyssynchrony by echocardiogram.
期刊介绍:
The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.