Ya-Wen Zhong, Xiu-Fang Wang, Hong Ding, Sui-Jin Zheng, Cai-Hong Wang, Rui-Man Li
{"title":"管理早产早破膜：抗菌管理和新的治疗策略。","authors":"Ya-Wen Zhong, Xiu-Fang Wang, Hong Ding, Sui-Jin Zheng, Cai-Hong Wang, Rui-Man Li","doi":"10.1111/jog.70020","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal–fetal outcomes.</p>\n </section>\n </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Management of preterm premature rupture of membranes: Antimicrobial stewardship and novel therapeutic strategies\",\"authors\":\"Ya-Wen Zhong, Xiu-Fang Wang, Hong Ding, Sui-Jin Zheng, Cai-Hong Wang, Rui-Man Li\",\"doi\":\"10.1111/jog.70020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal–fetal outcomes.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16593,\"journal\":{\"name\":\"Journal of Obstetrics and Gynaecology Research\",\"volume\":\"51 9\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynaecology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70020\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynaecology Research","FirstCategoryId":"3","ListUrlMain":"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70020","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Management of preterm premature rupture of membranes: Antimicrobial stewardship and novel therapeutic strategies
Purpose
Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.
Methods
Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.
Results
Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.
Conclusions
Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal–fetal outcomes.
期刊介绍：
The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology.
The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
