Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral
{"title":"光防护的新替代品:层状硅酸盐衍生物的制备和评价及其作为防晒霜的应用。","authors":"Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral","doi":"10.1111/ics.70008","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs).</p><p><strong>Methods: </strong>For this study, we examined Diethylamino hydroxybenzoyl hexyl benzoate (DHHB), octyl methoxycinnamate (OMC), Bemotrizinol (BEMT) and Viscogel S4®, S7®, and B8® using a set of Saccharomyces cerevisiae mutant strains that are sensitive to UVA, UVB and Solar Simulated Light (SSL) to evaluate their photoprotective and mutagenic potential. Additionally, we developed delaminated nanocomposites by chemical intercalation reactions followed by ultrasonic treatment to enhance clay exfoliation. These nanocomposites were then characterized using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Light Scattering (DLS).</p><p><strong>Results: </strong>As a function of photoprotective action and safety, the combination of Viscogel S4® and OMC filter was chosen for nanocomposite development. Our results evidenced the intercalation of the OMC in the organoclay (S4 + OMC-NC). Survival and mutagenesis tests indicated a positive effect of the formulation, as it increased cell survival to SSL, even without reducing mutagenesis, while its respective physical mixture was unable to provide antimutagenic protection.</p><p><strong>Conclusion: </strong>S4 + OMC-NC showed promising results for photoprotection, offering cellular protection combined with antimutagenic effects upon SSL exposure. This formulation enables prospects for the preparation of new, effective and safe photoprotective formulations.</p>","PeriodicalId":13936,"journal":{"name":"International Journal of Cosmetic Science","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens.\",\"authors\":\"Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral\",\"doi\":\"10.1111/ics.70008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs).</p><p><strong>Methods: </strong>For this study, we examined Diethylamino hydroxybenzoyl hexyl benzoate (DHHB), octyl methoxycinnamate (OMC), Bemotrizinol (BEMT) and Viscogel S4®, S7®, and B8® using a set of Saccharomyces cerevisiae mutant strains that are sensitive to UVA, UVB and Solar Simulated Light (SSL) to evaluate their photoprotective and mutagenic potential. Additionally, we developed delaminated nanocomposites by chemical intercalation reactions followed by ultrasonic treatment to enhance clay exfoliation. These nanocomposites were then characterized using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Light Scattering (DLS).</p><p><strong>Results: </strong>As a function of photoprotective action and safety, the combination of Viscogel S4® and OMC filter was chosen for nanocomposite development. Our results evidenced the intercalation of the OMC in the organoclay (S4 + OMC-NC). Survival and mutagenesis tests indicated a positive effect of the formulation, as it increased cell survival to SSL, even without reducing mutagenesis, while its respective physical mixture was unable to provide antimutagenic protection.</p><p><strong>Conclusion: </strong>S4 + OMC-NC showed promising results for photoprotection, offering cellular protection combined with antimutagenic effects upon SSL exposure. This formulation enables prospects for the preparation of new, effective and safe photoprotective formulations.</p>\",\"PeriodicalId\":13936,\"journal\":{\"name\":\"International Journal of Cosmetic Science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Cosmetic Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ics.70008\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Cosmetic Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ics.70008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens.
Objective: The objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs).
Methods: For this study, we examined Diethylamino hydroxybenzoyl hexyl benzoate (DHHB), octyl methoxycinnamate (OMC), Bemotrizinol (BEMT) and Viscogel S4®, S7®, and B8® using a set of Saccharomyces cerevisiae mutant strains that are sensitive to UVA, UVB and Solar Simulated Light (SSL) to evaluate their photoprotective and mutagenic potential. Additionally, we developed delaminated nanocomposites by chemical intercalation reactions followed by ultrasonic treatment to enhance clay exfoliation. These nanocomposites were then characterized using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Light Scattering (DLS).
Results: As a function of photoprotective action and safety, the combination of Viscogel S4® and OMC filter was chosen for nanocomposite development. Our results evidenced the intercalation of the OMC in the organoclay (S4 + OMC-NC). Survival and mutagenesis tests indicated a positive effect of the formulation, as it increased cell survival to SSL, even without reducing mutagenesis, while its respective physical mixture was unable to provide antimutagenic protection.
Conclusion: S4 + OMC-NC showed promising results for photoprotection, offering cellular protection combined with antimutagenic effects upon SSL exposure. This formulation enables prospects for the preparation of new, effective and safe photoprotective formulations.
期刊介绍:
The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes.
The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.