光防护的新替代品:层状硅酸盐衍生物的制备和评价及其作为防晒霜的应用。

IF 2.5 4区 医学 Q2 DERMATOLOGY
Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral
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引用次数: 0

摘要

目的:利用新方法(NAMs)研究不同防晒剂和粘胶基有机粘土制备新型插层防晒剂,以提高其光防护的有效性和安全性。方法:利用一组对UVA、UVB和太阳模拟光(SSL)敏感的酵母突变菌株,对二乙胺羟基苯甲酰己基苯甲酸酯(DHHB)、甲氧基肉桂酸辛基(OMC)、Bemotrizinol (BEMT)和粘胶S4®、S7®和B8®进行检测,评价其光保护和诱变潜力。此外,我们通过化学插层反应和超声波处理来开发分层纳米复合材料,以增强粘土的剥落。然后用x射线粉末衍射(XRPD)、差示扫描量热法(DSC)、热重分析(TGA)和动态光散射(DLS)对这些纳米复合材料进行了表征。结果:由于具有光防护作用和安全性,选择了粘胶S4®和OMC过滤器的组合进行纳米复合材料的开发。我们的结果证明了OMC在有机黏土中的插层作用(S4 + OMC- nc)。存活和诱变试验表明,该配方具有积极作用,因为即使不减少诱变,它也能增加细胞对SSL的存活,而其各自的物理混合物无法提供抗诱变保护。结论:S4 + OMC-NC具有良好的光保护效果,在SSL照射下具有细胞保护和抗诱变作用。该配方为制备新的、有效的、安全的光防护配方提供了前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens.

Objective: The objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs).

Methods: For this study, we examined Diethylamino hydroxybenzoyl hexyl benzoate (DHHB), octyl methoxycinnamate (OMC), Bemotrizinol (BEMT) and Viscogel S4®, S7®, and B8® using a set of Saccharomyces cerevisiae mutant strains that are sensitive to UVA, UVB and Solar Simulated Light (SSL) to evaluate their photoprotective and mutagenic potential. Additionally, we developed delaminated nanocomposites by chemical intercalation reactions followed by ultrasonic treatment to enhance clay exfoliation. These nanocomposites were then characterized using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Light Scattering (DLS).

Results: As a function of photoprotective action and safety, the combination of Viscogel S4® and OMC filter was chosen for nanocomposite development. Our results evidenced the intercalation of the OMC in the organoclay (S4 + OMC-NC). Survival and mutagenesis tests indicated a positive effect of the formulation, as it increased cell survival to SSL, even without reducing mutagenesis, while its respective physical mixture was unable to provide antimutagenic protection.

Conclusion: S4 + OMC-NC showed promising results for photoprotection, offering cellular protection combined with antimutagenic effects upon SSL exposure. This formulation enables prospects for the preparation of new, effective and safe photoprotective formulations.

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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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