化妆品中可能使用的内分泌干扰化学品清单。

IF 4.1 2区 医学 Q1 TOXICOLOGY
Critical Reviews in Toxicology Pub Date : 2025-01-01 Epub Date: 2025-09-11 DOI:10.1080/10408444.2025.2539186
Manon C Bouwmeester, Gaby A M Eliesen, Jeroen L A Pennings, Susan W P Wijnhoven, Ellen V S Hessel
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引用次数: 0

摘要

人们担心化妆品成分的安全性及其内分泌干扰(ED)的潜力。频繁使用和使用各种各样的化妆品,通过大量接触内分泌干扰化学品(EDCs),对潜在的健康风险构成了关注。在这项研究中,从Mintel商业数据库中检索了最近进入荷兰市场的化妆品中可用的成分清单,并对EDCs的存在进行了筛选。为了实现这一目标,开发了一个工作流程,将化妆品成分清单与来自开源计划的潜在EDCs信息(即来自欧洲化学品管理局、国家当局和非政府组织的化学品清单)进行交叉核对。使用该工作流程,在审查的890种化妆品成分中,确定了27种化学物质被归类为“ED特性适应症”,一种化学物质被归类为“不关注ED特性”。对其中一种化学物质香叶醇进行了初步的安全评估。通过化妆品对香叶醇的总体暴露使用PACEMweb进行建模,并与一项延长一代研究中观察到的甲状腺组织病理学最低不良反应水平进行比较。这项研究表明,根据目前可获得的信息,香叶醇可以安全地用于化妆品中,但不会造成与内分泌有关的健康风险。接下来,目前未被确定为EDC的化妆品成分(即未出现在交叉检查列表中,n = 862),根据总体暴露评分进行优先排序,以进一步筛选其内分泌干扰特性(n = 58)。从文献检索中检索到的58种优先化学物质数据中,有8种显示出内分泌介导的关系,并被归类为“ED特性的有限适应症”。总的来说,开发的工作流程是一个有用的工具,用于筛选化妆品中潜在的EDCs的存在,并优先考虑化学物质,以进一步评估其ED特性,以及评估其在化妆品中的安全使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inventory of possible endocrine disrupting chemicals used in cosmetic products.

There is a concern on the safety of cosmetic ingredients and their endocrine-disrupting (ED) potential. Frequent use as well as the use of a diverse range of cosmetics pose a concern for a potential health risk via aggregate exposure to endocrine disrupting chemicals (EDCs). In this study, a list of ingredients available in cosmetic products that were recently introduced to the Dutch market was retrieved from the commercially accessible Mintel database and screened for the presence of EDCs. To achieve this, a workflow was developed to crosscheck the list of cosmetic ingredients with information on potential EDCs derived from open-source initiatives (i.e. chemical lists from the European Chemicals Agency, national authorities, and non-governmental organizations). Using this workflow, 27 chemicals were identified that were categorized as "indications for ED properties" and one chemical as "no concern for ED properties" out of the 890 cosmetic ingredients reviewed. For one of these chemicals, geraniol, a preliminary safety assessment was performed. Aggregated exposure to geraniol via cosmetics was modeled using PACEMweb and compared to the lowest observed adverse effect level on thyroid histopathology derived from an extended-one-generation study. This exercise showed that, based on the current information available, geraniol can be used safely in cosmetics with regard to endocrine-related health risks. Next, the cosmetic ingredients that are currently not identified as an EDC (i.e. not present on one of the crosschecked lists, n = 862), were prioritized based on an aggregate exposure score for further screening of their endocrine disrupting properties (n = 58). For eight out of the 58 prioritized chemicals data retrieved from a literature search indicated an endocrine-mediated relationship, and were categorized as "limited indications of ED properties". Overall, the developed workflow is a useful tool to screen cosmetics for the presence of potential EDCs and to prioritize chemicals for further evaluation of their ED properties, as well as assessment of their safe use in cosmetics.

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来源期刊
CiteScore
9.50
自引率
1.70%
发文量
29
期刊介绍: Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.
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