[Spatio-temporal analysis of deaths due to pre-eclampsia in the national scenario (2009-2020)].

Population-based studies related to pre-eclampsia are scarce. The aim was to analyze the spatial and temporal distribution of deaths due to pre-eclampsia in Brazil from 2009 to 2020, characterizing the sociodemographic profile, distribution pattern, and presence of spatio-temporal clusters. It involved an ecological, population-based study using the Brazilian territory as the unit of analysis. The population was made up of all deaths of pregnant and postpartum women reported in Brazil, from 2009 to 2020, with pre-eclampsia as the underlying and/or associated cause. The data were obtained from the Mortality Information System. The temporal trend of mortality indicators was calculated using joinpoint regression models and standardized by age. To analyze the spatial distribution and spatio-temporal pattern of the outcome, geoprocessing techniques were used. The results point to the registration of 4,095 deaths associated with PE in 8.9% of Brazilian municipalities. High-risk spatial clusters of greater magnitude were identified in the Northeast, in 31 municipalities, compared to low-risk clusters in the Southeast and South regions. The results indicate a predominant upward trend in the outcome in Brazilian territory, associated with variables related to social vulnerability.