Ovarian cancer mortality in the states of Northeast and South Brazil (1980-2019): effect of age-period and cohort.

The scope of this study was to conduct an analysis on the effect of the Age-Period-Cohort (APC) on ovarian cancer mortality in the South and Northeast regions of Brazil. The APC models were estimated by Poisson regression through estimable functions in women aged 30 and over residing in the states of the South and Northeast regions. Upon estimating the APC models, a positive gradient was found in mortality rates with advancing age in all locations The South region showed a reduction in the risk of death in the last two periods (RR2010-2014 0.94; RR2015-2019 0.90, p<0.001) and a reduction in risk in the cohorts from 1900 to 1929 (RR1900-04 0.55, RR1925-1929 0.89, p<0.001); a similar profile was observed in all states. In the Northeast, there was a progressive increase in the risk of death in the last periods, ranging from 1.02 to 1.11 (2010-2014 vs. 2015-2019, p<0.001). An increased risk of death was observed in younger cohorts, varying from 0.31 to 1.54 (cohort 1900-1904 vs. 1985-1989). Similar results were observed in most of the states.: The conclusion drawn is that heterogeneity in the APC effect on ovarian cancer mortality, which may be correlated with the different rates of the population aging process, changes in the reproductive behavior of women, and inequalities in access to health services.