通过集成软机器人装置治疗脑积水的不可堵塞脑室-腹膜分流系统:清除装置。

IF 3.3 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Yau C. Yun, David R. Santiago-Dieppa, Minghao Li, Aditya Vasan, Alexander Khalessi, James Friend
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引用次数: 0

摘要

脑室-腹膜(VP)分流梗阻,通常由脑室导管端口的蛋白质和脂肪堆积引起,阻碍脑脊液(CSF)流出,增加颅内压(ICP),导致脑积水。目前的治疗需要有创的分流器移除、再植入术或逆行冲洗。我们提出了下一代VP分流系统,通过外部驱动主动清除堵塞。我们的系统,被称为堵塞消除驱动器硅胶(clear),集成了一个柔软的,可膨胀的硅胶管在导管腔内。这种柔软的机器人插入物,能够承受900%的张力,可以膨胀以移除堵塞,然后放气以恢复流动。为了测试clear,我们开发了一个体外模型,模拟脑脊液的流动和阻塞,使用快速作用的堵塞剂。监测导管上游的ICP以评估其性能。当被3g堵塞剂堵塞时,ICP升高到30 cmH。在clear激活后,硅胶插入物通过导管端口膨胀并成功移除阻塞,在大约40秒内恢复基线ICP (~ 0 cmH[公式:见文本]0)。没有这个系统,阻塞持续存在,压力仍然升高。可视文件证实了作用机制。通过实现无创机械脱井,clear系统为静脉分流闭塞提供了一个很有前途的解决方案。我们的模型复制了分流阻塞和脑脊液动力学,为设备评估提供了一个测试平台。可膨胀插入物维持导管流动,并在梗阻后将ICP降至正常水平,这代表了脑积水治疗方式的潜在转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Uncloggable ventriculoperitoneal shunt system for hydrocephalus via an integrated soft robotic device: CLEARS device

Ventriculoperitoneal (VP) shunt obstruction, often caused by protein and fat accumulation at the ventricular catheter ports, impedes cerebrospinal fluid (CSF) outflow, increases intracranial pressure (ICP), and leads to hydrocephalus. Current treatments require invasive shunt removal, reimplantation, or retrograde flush cleansing. We present a next-generation VP shunt system that actively removes blockages via external actuation. Our system, called CLogging Elimination ActuatoR Silicone (CLEARS), integrates a soft, expandable silicone tube within the catheter lumen. This soft robotic insert, capable of 900% strain, can inflate to dislodge blockages and then deflate to restore flow. To test CLEARS, we developed an ex vivo model simulating CSF flow and obstruction using a rapidly acting clogging agent. ICP upstream of the catheter was monitored to evaluate performance. When obstructed with 3 g of the clogging agent, ICP rose to 30 cmH\(_2\)O. Upon CLEARS activation, the silicone insert expanded through catheter ports and successfully removed the clog, restoring baseline ICP (\(\sim\)0 cmH\(_2\)O) within approximately 40 s. Without the system, obstruction persisted and pressure remained elevated. Visual documentation confirmed the mechanism of action. The CLEARS system offers a promising solution to VP shunt occlusion by enabling non-invasive mechanical declogging. Our model replicates shunt obstruction and CSF dynamics, providing a testbed for device evaluation. The expandable insert maintained catheter flow and reduced ICP to normal levels after obstruction, representing a potential shift in how hydrocephalus is treated.

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来源期刊
Biomedical Microdevices
Biomedical Microdevices 工程技术-工程:生物医学
CiteScore
6.90
自引率
3.60%
发文量
32
审稿时长
6 months
期刊介绍: Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.
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