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3,3-二氟-2-芳基- 3h -吲哚与环酮的不对称曼尼希反应合成c2 -季吲哚-3-酮的高对映选择性和前所未有的非对映选择性

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC
Journal of Organic Chemistry Pub Date : 2025-09-11 DOI:10.1021/acs.joc.5c01028
Hongyu Zhang, , , Qimei Yu, , , Jianfeng Mu, , , Xinjie Liang, , , Xiao Liu, , , Xiaochen Wang, , , Li Tang*, , , Bei Wei*, , and , Shurong Ban*, 
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引用次数: 0

摘要

本文描述了手性磷酸（CPA）催化3,3-二氟-2-芳基- 3h -吲哚与环酮合成c2 -季吲哚-3-酮的不对称曼尼希反应。该方法的显著特点是：(1)具有前所未有的非对映选择性和高立体选择性；(2)获取未完全探索的非对映体。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

High Enantioselective and Unprecedented Diastereoselective Synthesis of C2-Quaternary Indolin-3-ones by CPA-Catalyzed Asymmetric Mannich Reaction of 3,3-Difluoro-2-aryl-3H-indoles with Cycloketones

High Enantioselective and Unprecedented Diastereoselective Synthesis of C2-Quaternary Indolin-3-ones by CPA-Catalyzed Asymmetric Mannich Reaction of 3,3-Difluoro-2-aryl-3H-indoles with Cycloketones

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High Enantioselective and Unprecedented Diastereoselective Synthesis of C2-Quaternary Indolin-3-ones by CPA-Catalyzed Asymmetric Mannich Reaction of 3,3-Difluoro-2-aryl-3H-indoles with Cycloketones

Described here is a chiral phosphoric acid (CPA)-catalyzed asymmetric Mannich reaction of 3,3-difluoro-2-aryl-3H-indoles with cycloketones to produce C2-quaternary indolin-3-ones. Notable features of this method include: (1) unprecedented diastereoselectivity and high stereoselectivity; (2) access to not-fully-explored diastereomers.

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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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