{"title":"宿主转移RNA引导病毒RNA聚合酶的组装","authors":"","doi":"10.1038/s41594-025-01654-x","DOIUrl":null,"url":null,"abstract":"Transfer RNAs (tRNAs) are best known for their role in decoding messenger RNA codons and translating them into amino acids. A comprehensive biochemical and structural investigation of the poxviral transcription apparatus uncovers a thus far unknown role of specific host tRNAs as assembly chaperones for a multisubunit RNA polymerase complex.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"18 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Host transfer RNA guides assembly of viral RNA polymerase\",\"authors\":\"\",\"doi\":\"10.1038/s41594-025-01654-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Transfer RNAs (tRNAs) are best known for their role in decoding messenger RNA codons and translating them into amino acids. A comprehensive biochemical and structural investigation of the poxviral transcription apparatus uncovers a thus far unknown role of specific host tRNAs as assembly chaperones for a multisubunit RNA polymerase complex.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"18 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01654-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01654-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Host transfer RNA guides assembly of viral RNA polymerase
Transfer RNAs (tRNAs) are best known for their role in decoding messenger RNA codons and translating them into amino acids. A comprehensive biochemical and structural investigation of the poxviral transcription apparatus uncovers a thus far unknown role of specific host tRNAs as assembly chaperones for a multisubunit RNA polymerase complex.
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