Nature structural & molecular biology

TMPRSS2-mediated coronavirus spike activation and inhibition.

Pub Date : 2026-04-28 DOI: 10.1038/s41594-026-01801-y Matthew McCallum,James Brett Case,Jack T Brown,Young-Jun Park,Jimin Lee,Emmajay Sutherland,Anupriya Aggarwal,Cecily Gibson,Florian A Lempp,Cameron Stewart,M Alejandra Tortorici,Shilpa Sanapala,Jun Siong Low,Daniel Asarnow,Dana Bohan,Exequiel Dellota,Benjamin Merz,Bhavna Chawla,Swagata Kar,Antonio Lanzavecchia,Federica Sallusto,Nicholas M Riley,Stuart Turville,Lisa Purcell,Michael S Diamond,David Veesler

Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation.

Pub Date : 2026-04-22 DOI: 10.1038/s41594-026-01796-6 Yashpal Rawal,Youngho Kwon,Lijia Jia,Eliza A Ruben,Jae-Hoon Ji,Lijuan Guo,Caleb M Stratton,Digant Nayak,Miriam Tovar,Qingming Fang,Mohd Azrin Jamalruddin,Shuo Zhou,Sahiti Kuppa,Shahrez Syed,Angela M Jasper,Jeffrey N Katz,Cody M Rogers,Hardeep Kaur,Lorena Samentar,Weixing Zhao,Eloise Dray,Fang Zhang,Svetla Stoilova-McPhie,Alexander B Taylor,Sandeep Burma,Manjeet K Rao,David S Libich,Robert Hromas,Alexander V Mazin,Maria Jasin,Daohong Zhou,Kara A Bernstein,Eric C Greene,Elizabeth V Wasmuth,Patrick Sung,Shaun K Olsen

Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency.

Pub Date : 2026-04-13 DOI: 10.1038/s41594-026-01788-6 Kaoling Guan,Rodrigo Fregoso Ocampo,Paula B Matheus Carnevali,Cindy J Castelle,Liliana Gonzalez-Osorio,Dominic T Castanzo,Nicole C Thomas,Molly Brothers,Tyler L Dangerfield,Matthew M Hooper,Madeline S West,Nathan M Appleby,Isabella Krudop,Rebecca C Lamothe,Daniela S Aliaga Goltsman,Lisa M Alexander,Cristina N Butterfield,Kenneth A Johnson,Christopher T Brown,David W Taylor