Nature structural & molecular biology

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Nature structural & molecular biology - 最新文献

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation

Pub Date : 2025-05-02 DOI: 10.1038/s41594-025-01533-5 Chengming Zhu, Xiaoyue Si, Xinhao Hou, Panpan Xu, Jianing Gao, Yao Tang, Chenchun Weng, Mingjing Xu, Qi Yan, Qile Jin, Jiewei Cheng, Ke Ruan, Ying Zhou, Ge Shan, Demin Xu, Xiangyang Chen, Shengqi Xiang, Xinya Huang, Xuezhu Feng, Shouhong Guang

Gating mechanism of the two-pore-domain potassium channel THIK1

Pub Date : 2025-04-30 DOI: 10.1038/s41594-025-01542-4 Xiangyun Fang, Haichao Jin, Jin Wang, Ran Zhang, Baobin Li

Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation

Pub Date : 2025-04-28 DOI: 10.1038/s41594-025-01537-1 Yanran Li, Kaiwen Bao, Jiyue Sun, Ruixin Ge, Qiqing Zhang, Bing Zhang, Xiaojie Yan, Junlin Li, Fengying Shi, Meiling Zhang, Jinzhi Zang, Min Liu, Jun Zhou, Wenyi Mi, Songbo Xie, Dongxing Chen, Lei Shi, Cheng Dong

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