IgSF蛋白DIP-α和Dpr10的关键亲和力窗口是运动神经元正常树突化所必需的

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-09-10 DOI:10.1101/gad.352936.125

Davys H. Lopez, Kevin D. Rostam, Sumaira Zamurrad, Shuwa Xu, Richard S. Mann

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引用次数: 0

摘要

为了使神经元在动物神经系统中建立正确的连接，细胞粘附分子（CAMs）之间的相互作用，在突触前和突触后表达，被认为是引导神经元到它们的目标。在这里，我们评估了两个同源cam - dip -α和dpr10之间的亲和力在果蝇腿部神经肌肉系统的建立中所起的作用。如果亲和性降低或出乎意料地增加超过一定阈值，运动神经元（MN）末端分支就不能维持。发育过程中的实时成像显示，当亲和性异常时，MN丝状足无法有效地接合其肌肉目标。因此，CAM亲和性被调整以获得适当的神经元形态。

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A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization

For neurons to establish the correct connections in animal nervous systems, interactions between cell adhesion molecules (CAMs), expressed presynaptically and postsynaptically, are thought to guide neurons to their targets. Here, we assess the role that affinity between two cognate CAMs—DIP-α and Dpr10—plays in establishing the leg neuromuscular system in Drosophila. If affinity decreases or, surprisingly, increases past certain thresholds, motor neuron (MN) terminal branches fail to be maintained. Live imaging during development shows that when affinities are aberrant, MN filopodia are unable to productively engage their muscle targets. Thus, CAM affinities are tuned to achieve proper neuronal morphology.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).