Edward S Lu, Yifan Lu, Ying Cui, Rebecca Zeng, Ying Zhu, Xinyi Ding, Raviv Katz, Rongrong Le, Itika Garg, Jay C Wang, Demetrios G Vavvas, Deeba Husain, Joan W Miller, David M Wu, John B Miller
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Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.</p><p><strong>Conclusion: </strong>Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. SS-OCTA may be useful for predicting diabetic TRD development.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expanded field OCTA Biomarkers Associated with the Development of Tractional Retinal Detachment in Proliferative Diabetic Retinopathy.\",\"authors\":\"Edward S Lu, Yifan Lu, Ying Cui, Rebecca Zeng, Ying Zhu, Xinyi Ding, Raviv Katz, Rongrong Le, Itika Garg, Jay C Wang, Demetrios G Vavvas, Deeba Husain, Joan W Miller, David M Wu, John B Miller\",\"doi\":\"10.1097/IAE.0000000000004661\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders. A logistic regression model was utilized to identify OCTA biomarkers associated with TRD development.</p><p><strong>Results: </strong>Forty-nine PDR eyes from 38 participants were included. Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.</p><p><strong>Conclusion: </strong>Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. 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引用次数: 0
摘要
目的：探讨增生性糖尿病视网膜病变（PDR）患者扩展场扫描源光学相干断层血管造影（SS-OCTA）生物标志物与牵引性视网膜脱离（TRD）发生的关系。方法：对基线无TRD的PDR患者进行SS-OCTA成像。定量和定性OCTA指标由两名训练有素的评分员独立评估。采用逻辑回归模型鉴定与TRD发展相关的OCTA生物标志物。结果：包括38名参与者的49只PDR眼。49只眼中有7只（14%）在中位576天（范围35-805天）内发生TRD。与TRD相关的生物标志物有：视网膜非灌注面积大（NPA）（优势比[OR]， 7.84； 95%可信区间[CI]， 2.61 - 16.3; p = 0.04），新生血管（NV）的存在，总面积为bbbb4盘直径，（OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04），以及出现tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02)，定义为NV通过玻璃体牵引前移位，但通过血管膜系在视网膜上。结论：视网膜NPA大、NV广泛、NV伴玻璃体牵拉前移位与TRD发生风险增加有关。SS-OCTA可能有助于预测糖尿病TRD的发展。
Expanded field OCTA Biomarkers Associated with the Development of Tractional Retinal Detachment in Proliferative Diabetic Retinopathy.
Purpose: To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).
Methods: Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders. A logistic regression model was utilized to identify OCTA biomarkers associated with TRD development.
Results: Forty-nine PDR eyes from 38 participants were included. Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.
Conclusion: Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. SS-OCTA may be useful for predicting diabetic TRD development.
期刊介绍：
RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice.
In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color.
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