{"title":"基于ev的骨关节炎无细胞治疗的全球研究趋势：文献计量学分析。","authors":"Chuanhui Zhang, Chen Xu, Chengshuai Sun, Weining Meng","doi":"10.1007/s13770-025-00749-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.</p><p><strong>Methods: </strong>Publications related to OA and Cell-free therapy based on EVs were retrieved from the Web of Science Core Collection database from 1991 to 2024. Our study employed bibliometric methods to analyze publication trends, leading contributing countries, institutions, authors, journals, and emerging trends and research directions.</p><p><strong>Results: </strong>The analysis has revealed a rapid growth in publications since 2019. China dominated both in terms of publication output and citation counts. The most productive institution is Shanghai Jiao Tong University. The most prolific publishing outlet journal was the International Journal of Molecular Sciences, while in terms of citation impact, Biomaterials ranked first. De Girolamo, Laura from Aix-Marseille Universite and Ragni, Enrico from IRCCS Istituto Ortopedico Galeazzi shared the top position in publication output, while Noel, Daniele from the Universite de Montpellier was the author receiving the most citations. Research primarily clustered around key themes including: (1) therapeutic mechanisms of cell-free treatment based on EVs in OA, (2) research advances in cell-free treatment based on EVs, (3) exosome engineering, and (4) a novel drug delivery system for EVs.</p><p><strong>Conclusion: </strong>This is the first bibliometric study on cell-free therapy based on EVs for OA, providing orthopedic and regenerative medicine experts with comprehensive perspectives on the field's current status and future development directions.</p>","PeriodicalId":23126,"journal":{"name":"Tissue engineering and regenerative medicine","volume":" ","pages":"911-928"},"PeriodicalIF":4.1000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476339/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global Research Trends in EV-Based Cell-Free Therapy for Osteoarthritis: A Bibliometric Analysis.\",\"authors\":\"Chuanhui Zhang, Chen Xu, Chengshuai Sun, Weining Meng\",\"doi\":\"10.1007/s13770-025-00749-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.</p><p><strong>Methods: </strong>Publications related to OA and Cell-free therapy based on EVs were retrieved from the Web of Science Core Collection database from 1991 to 2024. Our study employed bibliometric methods to analyze publication trends, leading contributing countries, institutions, authors, journals, and emerging trends and research directions.</p><p><strong>Results: </strong>The analysis has revealed a rapid growth in publications since 2019. China dominated both in terms of publication output and citation counts. The most productive institution is Shanghai Jiao Tong University. The most prolific publishing outlet journal was the International Journal of Molecular Sciences, while in terms of citation impact, Biomaterials ranked first. De Girolamo, Laura from Aix-Marseille Universite and Ragni, Enrico from IRCCS Istituto Ortopedico Galeazzi shared the top position in publication output, while Noel, Daniele from the Universite de Montpellier was the author receiving the most citations. Research primarily clustered around key themes including: (1) therapeutic mechanisms of cell-free treatment based on EVs in OA, (2) research advances in cell-free treatment based on EVs, (3) exosome engineering, and (4) a novel drug delivery system for EVs.</p><p><strong>Conclusion: </strong>This is the first bibliometric study on cell-free therapy based on EVs for OA, providing orthopedic and regenerative medicine experts with comprehensive perspectives on the field's current status and future development directions.</p>\",\"PeriodicalId\":23126,\"journal\":{\"name\":\"Tissue engineering and regenerative medicine\",\"volume\":\" \",\"pages\":\"911-928\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476339/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tissue engineering and regenerative medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s13770-025-00749-2\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tissue engineering and regenerative medicine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s13770-025-00749-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0
摘要
背景：骨关节炎（OA）是一项重大的全球健康挑战，目前尚无理想的治疗方案。早期治疗通常侧重于缓解疼痛和僵硬的症状；而晚期患者只能选择手术干预，如关节置换术来改善生活质量。基于细胞外囊泡（EVs）的无细胞治疗为调节骨代谢和修复软骨提供了一种新的治疗方法，显示出新兴的潜力。方法：从Web of Science Core Collection数据库中检索1991 - 2024年与OA和基于EVs的无细胞治疗相关的出版物。本研究采用文献计量学方法分析了文献出版趋势、主要贡献国家、机构、作者、期刊、新兴趋势和研究方向。结果：分析显示，自2019年以来，出版物快速增长。中国在发表量和引用量方面都占主导地位。生产力最高的机构是上海交通大学。发表最多的期刊是《International journal of Molecular Sciences》，引用影响力排名第一的是《Biomaterials》。来自艾克斯-马赛大学的De Girolamo， Laura和来自IRCCS Ortopedico Galeazzi研究所的Ragni， Enrico在发表量方面并列第一，而来自蒙比利埃大学的Noel， Daniele是被引用次数最多的作者。研究主要集中在以下几个关键主题上：(1)基于ev的无细胞治疗OA的治疗机制；(2)基于ev的无细胞治疗的研究进展；(3)外泌体工程；(4)ev的新型给药系统。结论：这是首次基于ev的无细胞治疗OA的文献计量学研究，为骨科和再生医学专家提供了该领域的现状和未来发展方向的全面视角。
Global Research Trends in EV-Based Cell-Free Therapy for Osteoarthritis: A Bibliometric Analysis.
Background: Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.
Methods: Publications related to OA and Cell-free therapy based on EVs were retrieved from the Web of Science Core Collection database from 1991 to 2024. Our study employed bibliometric methods to analyze publication trends, leading contributing countries, institutions, authors, journals, and emerging trends and research directions.
Results: The analysis has revealed a rapid growth in publications since 2019. China dominated both in terms of publication output and citation counts. The most productive institution is Shanghai Jiao Tong University. The most prolific publishing outlet journal was the International Journal of Molecular Sciences, while in terms of citation impact, Biomaterials ranked first. De Girolamo, Laura from Aix-Marseille Universite and Ragni, Enrico from IRCCS Istituto Ortopedico Galeazzi shared the top position in publication output, while Noel, Daniele from the Universite de Montpellier was the author receiving the most citations. Research primarily clustered around key themes including: (1) therapeutic mechanisms of cell-free treatment based on EVs in OA, (2) research advances in cell-free treatment based on EVs, (3) exosome engineering, and (4) a novel drug delivery system for EVs.
Conclusion: This is the first bibliometric study on cell-free therapy based on EVs for OA, providing orthopedic and regenerative medicine experts with comprehensive perspectives on the field's current status and future development directions.
期刊介绍：
Tissue Engineering and Regenerative Medicine (Tissue Eng Regen Med, TERM), the official journal of the Korean Tissue Engineering and Regenerative Medicine Society, is a publication dedicated to providing research- based solutions to issues related to human diseases. This journal publishes articles that report substantial information and original findings on tissue engineering, medical biomaterials, cells therapy, stem cell biology and regenerative medicine.
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