{"title":"阿根廷一所大学医院多重耐药铜绿假单胞菌分离株的抗微生物药物耐药性概况。新抗生素组合的活性。","authors":"Carla Alvarez, Juliana Bello, Carlos Vay, Ángela Famiglietti, Marcela Nastro, Hernán Rodríguez","doi":"10.1016/j.ram.2025.07.003","DOIUrl":null,"url":null,"abstract":"<p><p>Thirty consecutive multidrug-resistant non-carbapenemase-producing Pseudomonas aeruginosa clinical isolates from patients admitted at a university hospital were studied. Resistance rates to ceftazidime/avibactam, aztreonam/avibactam, ceftolozane/tazobactam and imipenem/relebactam were 40%, 88%, 3%, and 20%, respectively. Ceftazidime/avibactam reverted ceftazidime resistance in 25% of the isolates, whereas imipenem/relebactam did so in 77% of the imipenem-resistant isolates. The analysis of the resistance patterns observed suggests a high contribution of non-enzymatic mechanisms such as efflux pumps and porin alterations.</p>","PeriodicalId":21163,"journal":{"name":"Revista Argentina de microbiologia","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial resistance profiles in multidrug-resistant Pseudomonas aeruginosa isolates in a university hospital in Argentina. Activity of new antibiotic combinations.\",\"authors\":\"Carla Alvarez, Juliana Bello, Carlos Vay, Ángela Famiglietti, Marcela Nastro, Hernán Rodríguez\",\"doi\":\"10.1016/j.ram.2025.07.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Thirty consecutive multidrug-resistant non-carbapenemase-producing Pseudomonas aeruginosa clinical isolates from patients admitted at a university hospital were studied. Resistance rates to ceftazidime/avibactam, aztreonam/avibactam, ceftolozane/tazobactam and imipenem/relebactam were 40%, 88%, 3%, and 20%, respectively. Ceftazidime/avibactam reverted ceftazidime resistance in 25% of the isolates, whereas imipenem/relebactam did so in 77% of the imipenem-resistant isolates. The analysis of the resistance patterns observed suggests a high contribution of non-enzymatic mechanisms such as efflux pumps and porin alterations.</p>\",\"PeriodicalId\":21163,\"journal\":{\"name\":\"Revista Argentina de microbiologia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Argentina de microbiologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ram.2025.07.003\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Argentina de microbiologia","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.ram.2025.07.003","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Antimicrobial resistance profiles in multidrug-resistant Pseudomonas aeruginosa isolates in a university hospital in Argentina. Activity of new antibiotic combinations.
Thirty consecutive multidrug-resistant non-carbapenemase-producing Pseudomonas aeruginosa clinical isolates from patients admitted at a university hospital were studied. Resistance rates to ceftazidime/avibactam, aztreonam/avibactam, ceftolozane/tazobactam and imipenem/relebactam were 40%, 88%, 3%, and 20%, respectively. Ceftazidime/avibactam reverted ceftazidime resistance in 25% of the isolates, whereas imipenem/relebactam did so in 77% of the imipenem-resistant isolates. The analysis of the resistance patterns observed suggests a high contribution of non-enzymatic mechanisms such as efflux pumps and porin alterations.
期刊介绍:
La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.