阿根廷一所大学医院多重耐药铜绿假单胞菌分离株的抗微生物药物耐药性概况。新抗生素组合的活性。

IF 2.1 4区 生物学 Q4 MICROBIOLOGY
Carla Alvarez, Juliana Bello, Carlos Vay, Ángela Famiglietti, Marcela Nastro, Hernán Rodríguez
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引用次数: 0

摘要

对从某大学医院住院患者连续分离的30株耐多药非产碳青霉烯酶铜绿假单胞菌进行了研究。头孢他啶/阿维巴坦耐药率为40%,阿曲南/阿维巴坦耐药率为88%,头孢甲苯/他唑巴坦耐药率为3%,亚胺培南/瑞巴坦耐药率为20%。头孢他啶/阿维巴坦在25%的分离株中恢复了头孢他啶耐药性,而亚胺培南/瑞巴坦在77%的亚胺培南耐药分离株中恢复了头孢他啶耐药性。对观察到的抗性模式的分析表明,非酶机制如外排泵和孔蛋白改变的高贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial resistance profiles in multidrug-resistant Pseudomonas aeruginosa isolates in a university hospital in Argentina. Activity of new antibiotic combinations.

Thirty consecutive multidrug-resistant non-carbapenemase-producing Pseudomonas aeruginosa clinical isolates from patients admitted at a university hospital were studied. Resistance rates to ceftazidime/avibactam, aztreonam/avibactam, ceftolozane/tazobactam and imipenem/relebactam were 40%, 88%, 3%, and 20%, respectively. Ceftazidime/avibactam reverted ceftazidime resistance in 25% of the isolates, whereas imipenem/relebactam did so in 77% of the imipenem-resistant isolates. The analysis of the resistance patterns observed suggests a high contribution of non-enzymatic mechanisms such as efflux pumps and porin alterations.

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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
46
审稿时长
>12 weeks
期刊介绍: La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.
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