Leonardo Teti, Alicia Pérez-Idarraga, Marta Salcedo-Miranda, Alberto Cacho, Fara Yeste-Ojeda, Conchita Martin
{"title":"正畸矫正器间歇振动力对牙根吸收影响的随机临床试验。","authors":"Leonardo Teti, Alicia Pérez-Idarraga, Marta Salcedo-Miranda, Alberto Cacho, Fara Yeste-Ojeda, Conchita Martin","doi":"10.1111/ocr.70028","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of this RCT was to analyse the relationship between intermittent vibratory forces and external apical root resorption (EARR) in patients treated with clear aligners, building on prior research on vibrational effects on biomarkers.</p><p><strong>Materials and methods: </strong>A parallel, three-arm randomised clinical trial included adults to be treated with clear aligners, randomly assigned by a computerised randomisation list to: Group A (vibration from treatment onset), Group B (vibration after 6 weeks), or Group C (no vibration). While patients and orthodontists were aware of group assignments, evaluators remained blinded. Digital orthopantomographs (OPGs) taken at treatment initiation (T0) and completion (T4) were analysed using Linge & Linge, Fritz & Krieger, and Malmgren methods. Crevicular fluid levels of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) were measured as bone remodelling markers at different time points (T0, T1, T2, T3, T4).</p><p><strong>Results: </strong>Fifteen patients were analysed in Groups A and C, and 14 in Group B. No significant differences in EARR were found between groups, except for a significant increase in Group B (T2-T0) using Fritz & Krieger correlated with OPG (p = 0.010). Mean EARR was 4.13% (Group A), 4.08% (Group B), and 2.52% (Group C) using Linge & Linge; and 3.26%, 2.82%, and 2.12%, respectively, using Fritz & Krieger. No adverse effects were observed.</p><p><strong>Conclusion: </strong>The effect of intermittent vibratory forces on EARR remains inconclusive, highlighting the need for further research to optimise vibration protocols and understand its impact.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05316636.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption.\",\"authors\":\"Leonardo Teti, Alicia Pérez-Idarraga, Marta Salcedo-Miranda, Alberto Cacho, Fara Yeste-Ojeda, Conchita Martin\",\"doi\":\"10.1111/ocr.70028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of this RCT was to analyse the relationship between intermittent vibratory forces and external apical root resorption (EARR) in patients treated with clear aligners, building on prior research on vibrational effects on biomarkers.</p><p><strong>Materials and methods: </strong>A parallel, three-arm randomised clinical trial included adults to be treated with clear aligners, randomly assigned by a computerised randomisation list to: Group A (vibration from treatment onset), Group B (vibration after 6 weeks), or Group C (no vibration). While patients and orthodontists were aware of group assignments, evaluators remained blinded. Digital orthopantomographs (OPGs) taken at treatment initiation (T0) and completion (T4) were analysed using Linge & Linge, Fritz & Krieger, and Malmgren methods. Crevicular fluid levels of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) were measured as bone remodelling markers at different time points (T0, T1, T2, T3, T4).</p><p><strong>Results: </strong>Fifteen patients were analysed in Groups A and C, and 14 in Group B. No significant differences in EARR were found between groups, except for a significant increase in Group B (T2-T0) using Fritz & Krieger correlated with OPG (p = 0.010). Mean EARR was 4.13% (Group A), 4.08% (Group B), and 2.52% (Group C) using Linge & Linge; and 3.26%, 2.82%, and 2.12%, respectively, using Fritz & Krieger. No adverse effects were observed.</p><p><strong>Conclusion: </strong>The effect of intermittent vibratory forces on EARR remains inconclusive, highlighting the need for further research to optimise vibration protocols and understand its impact.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05316636.</p>\",\"PeriodicalId\":19652,\"journal\":{\"name\":\"Orthodontics & Craniofacial Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Orthodontics & Craniofacial Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ocr.70028\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orthodontics & Craniofacial Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ocr.70028","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption.
Objective: The aim of this RCT was to analyse the relationship between intermittent vibratory forces and external apical root resorption (EARR) in patients treated with clear aligners, building on prior research on vibrational effects on biomarkers.
Materials and methods: A parallel, three-arm randomised clinical trial included adults to be treated with clear aligners, randomly assigned by a computerised randomisation list to: Group A (vibration from treatment onset), Group B (vibration after 6 weeks), or Group C (no vibration). While patients and orthodontists were aware of group assignments, evaluators remained blinded. Digital orthopantomographs (OPGs) taken at treatment initiation (T0) and completion (T4) were analysed using Linge & Linge, Fritz & Krieger, and Malmgren methods. Crevicular fluid levels of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) were measured as bone remodelling markers at different time points (T0, T1, T2, T3, T4).
Results: Fifteen patients were analysed in Groups A and C, and 14 in Group B. No significant differences in EARR were found between groups, except for a significant increase in Group B (T2-T0) using Fritz & Krieger correlated with OPG (p = 0.010). Mean EARR was 4.13% (Group A), 4.08% (Group B), and 2.52% (Group C) using Linge & Linge; and 3.26%, 2.82%, and 2.12%, respectively, using Fritz & Krieger. No adverse effects were observed.
Conclusion: The effect of intermittent vibratory forces on EARR remains inconclusive, highlighting the need for further research to optimise vibration protocols and understand its impact.
期刊介绍：
Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions.
The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements.
The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.
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