高毒力耐碳青霉烯肺炎克雷伯菌感染：流行病学、毒力、耐药性和治疗。

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S534490

Jinyan Yu, Yanlei Li, Qinghua Zhang, Yan Wang

{"title":"高毒力耐碳青霉烯肺炎克雷伯菌感染：流行病学、毒力、耐药性和治疗。","authors":"Jinyan Yu, Yanlei Li, Qinghua Zhang, Yan Wang","doi":"10.2147/IDR.S534490","DOIUrl":null,"url":null,"abstract":"In recent years, reports of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella pneumoniae (Kp) (hv-CRKp) have gradually increased. hv-CRKp may emerge from hvKp acquiring mobile genetic elements carrying multiple antibiotic-resistance genes or multi-drug-resistant Kp acquiring virulence genes, with subsequent convergence of resistance and virulence. Thus, hv-CRKp simultaneously harbors resistance and virulence genes and may even show resistance to colistin and tigecycline, suggesting potential for causing severe infections and placing a serious burden on the health care system. In this study, we review and summarize published literature on the epidemiology, virulence, resistance genes, and treatment of hv-CRKp.","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4689-4697"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416384/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hypervirulent Carbapenem-resistant Klebsiella pneumoniae Infection: Epidemiology, Virulence, Resistance, and Treatment.\",\"authors\":\"Jinyan Yu, Yanlei Li, Qinghua Zhang, Yan Wang\",\"doi\":\"10.2147/IDR.S534490\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, reports of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella pneumoniae (Kp) (hv-CRKp) have gradually increased. hv-CRKp may emerge from hvKp acquiring mobile genetic elements carrying multiple antibiotic-resistance genes or multi-drug-resistant Kp acquiring virulence genes, with subsequent convergence of resistance and virulence. Thus, hv-CRKp simultaneously harbors resistance and virulence genes and may even show resistance to colistin and tigecycline, suggesting potential for causing severe infections and placing a serious burden on the health care system. In this study, we review and summarize published literature on the epidemiology, virulence, resistance genes, and treatment of hv-CRKp.\",\"PeriodicalId\":13577,\"journal\":{\"name\":\"Infection and Drug Resistance\",\"volume\":\"18 \",\"pages\":\"4689-4697\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416384/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection and Drug Resistance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IDR.S534490\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Drug Resistance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IDR.S534490","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

近年来，高毒力（hv）耐碳青霉烯（CR）肺炎克雷伯菌（Kp）（hv- crkp）的报道逐渐增多。hv-CRKp可能来自携带多种抗生素耐药基因的获得hvKp的移动遗传元件或获得多重耐药Kp的毒力基因，随后的耐药性和毒力趋同。因此，hv-CRKp同时携带耐药和毒力基因，甚至可能对粘菌素和替加环素产生耐药性，这表明可能引起严重感染并给卫生保健系统带来严重负担。在本研究中，我们对hv-CRKp的流行病学、毒力、耐药基因和治疗方面的文献进行了回顾和总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hypervirulent Carbapenem-resistant Klebsiella pneumoniae Infection: Epidemiology, Virulence, Resistance, and Treatment.

查看原文本刊更多论文

Hypervirulent Carbapenem-resistant Klebsiella pneumoniae Infection: Epidemiology, Virulence, Resistance, and Treatment.

In recent years, reports of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella pneumoniae (Kp) (hv-CRKp) have gradually increased. hv-CRKp may emerge from hvKp acquiring mobile genetic elements carrying multiple antibiotic-resistance genes or multi-drug-resistant Kp acquiring virulence genes, with subsequent convergence of resistance and virulence. Thus, hv-CRKp simultaneously harbors resistance and virulence genes and may even show resistance to colistin and tigecycline, suggesting potential for causing severe infections and placing a serious burden on the health care system. In this study, we review and summarize published literature on the epidemiology, virulence, resistance genes, and treatment of hv-CRKp.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.