{"title":"甲苯醌调节肺癌细胞的NR1D1和昼夜节律:对昼夜节律医学的影响。","authors":"Nidhi Nagariya, Vihas Vasu, Kaushalkumar Chaudhari, Aparna Golani, Jyoti Vihas Thaikoottathil, Hetal Roy","doi":"10.1080/07420528.2025.2556834","DOIUrl":null,"url":null,"abstract":"<p><p>Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, <i>NR1D1</i> plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of <i>NR1D1</i> has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on <i>NR1D1</i> gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-23"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toluquinol modulates <i>NR1D1</i> and circadian rhythm in lung cancer cells: Implications for circadian medicine.\",\"authors\":\"Nidhi Nagariya, Vihas Vasu, Kaushalkumar Chaudhari, Aparna Golani, Jyoti Vihas Thaikoottathil, Hetal Roy\",\"doi\":\"10.1080/07420528.2025.2556834\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, <i>NR1D1</i> plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of <i>NR1D1</i> has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on <i>NR1D1</i> gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.</p>\",\"PeriodicalId\":10294,\"journal\":{\"name\":\"Chronobiology International\",\"volume\":\" \",\"pages\":\"1-23\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chronobiology International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/07420528.2025.2556834\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07420528.2025.2556834","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Toluquinol modulates NR1D1 and circadian rhythm in lung cancer cells: Implications for circadian medicine.
Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, NR1D1 plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of NR1D1 has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on NR1D1 gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.
期刊介绍:
Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study.
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