Linfeng Yang , Qingqing Wang , Rui Yang , Boyao Chen , Meng Li , Lingfei Guo
{"title":"产后抑郁症的神经成像生物标志物:结构、功能和代谢改变的综合综述。","authors":"Linfeng Yang , Qingqing Wang , Rui Yang , Boyao Chen , Meng Li , Lingfei Guo","doi":"10.1016/j.bbr.2025.115810","DOIUrl":null,"url":null,"abstract":"<div><div>Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors. Advances in neuroimaging have revealed structural, functional, and metabolic brain alterations associated with PPD. Specifically, structural MRI studies have shown gray matter volume changes in regions such as the dorsolateral prefrontal cortex and anterior insula, as well as white matter integrity changes in tracts like the internal capsule and cingulum. Functional MRI studies have revealed abnormal activity in regions including the amygdala, hippocampus, and prefrontal cortex, with altered functional connectivity within networks such as the default mode network. Metabolic studies using MRS and PET have identified imbalances in neurotransmitters like serotonin, glutamate, and GABA, as well as changes in brain metabolism.This review synthesizes these findings, highlighting potential biomarkers and implications for targeted treatments. Future research should focus on multimodal approaches, larger sample sizes, and longitudinal studies to further elucidate PPD's neurobiological basis and improve diagnosis and treatment.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115810"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuroimaging biomarkers in postpartum depression: A comprehensive review of structural, functional, and metabolic alterations\",\"authors\":\"Linfeng Yang , Qingqing Wang , Rui Yang , Boyao Chen , Meng Li , Lingfei Guo\",\"doi\":\"10.1016/j.bbr.2025.115810\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors. Advances in neuroimaging have revealed structural, functional, and metabolic brain alterations associated with PPD. Specifically, structural MRI studies have shown gray matter volume changes in regions such as the dorsolateral prefrontal cortex and anterior insula, as well as white matter integrity changes in tracts like the internal capsule and cingulum. Functional MRI studies have revealed abnormal activity in regions including the amygdala, hippocampus, and prefrontal cortex, with altered functional connectivity within networks such as the default mode network. Metabolic studies using MRS and PET have identified imbalances in neurotransmitters like serotonin, glutamate, and GABA, as well as changes in brain metabolism.This review synthesizes these findings, highlighting potential biomarkers and implications for targeted treatments. Future research should focus on multimodal approaches, larger sample sizes, and longitudinal studies to further elucidate PPD's neurobiological basis and improve diagnosis and treatment.</div></div>\",\"PeriodicalId\":8823,\"journal\":{\"name\":\"Behavioural Brain Research\",\"volume\":\"496 \",\"pages\":\"Article 115810\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Behavioural Brain Research\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0166432825003973\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioural Brain Research","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0166432825003973","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
Neuroimaging biomarkers in postpartum depression: A comprehensive review of structural, functional, and metabolic alterations
Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors. Advances in neuroimaging have revealed structural, functional, and metabolic brain alterations associated with PPD. Specifically, structural MRI studies have shown gray matter volume changes in regions such as the dorsolateral prefrontal cortex and anterior insula, as well as white matter integrity changes in tracts like the internal capsule and cingulum. Functional MRI studies have revealed abnormal activity in regions including the amygdala, hippocampus, and prefrontal cortex, with altered functional connectivity within networks such as the default mode network. Metabolic studies using MRS and PET have identified imbalances in neurotransmitters like serotonin, glutamate, and GABA, as well as changes in brain metabolism.This review synthesizes these findings, highlighting potential biomarkers and implications for targeted treatments. Future research should focus on multimodal approaches, larger sample sizes, and longitudinal studies to further elucidate PPD's neurobiological basis and improve diagnosis and treatment.
期刊介绍:
Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.