产后抑郁症的神经成像生物标志物:结构、功能和代谢改变的综合综述。

IF 2.3 3区 心理学 Q2 BEHAVIORAL SCIENCES
Linfeng Yang , Qingqing Wang , Rui Yang , Boyao Chen , Meng Li , Lingfei Guo
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引用次数: 0

摘要

产后抑郁(PPD)是影响许多新妈妈产后第一年的一种重要的围产期情绪障碍。它的特点是情绪、认知和行为改变,通常由于非特异性症状导致诊断延迟。PPD是神经内分泌、遗传和社会心理因素复杂相互作用的结果。神经影像学的进步揭示了与PPD相关的结构、功能和代谢脑改变。具体而言,结构性MRI研究显示,前额叶皮层背外侧和脑岛前部等区域的灰质体积发生变化,内囊和扣带等脑束的白质完整性发生变化。功能性MRI研究显示,杏仁核、海马体和前额皮质等区域异常活动,并改变了默认模式网络等网络内的功能连接。利用MRS和PET进行的代谢研究已经确定了5 -羟色胺、谷氨酸和氨基丁酸等神经递质的失衡,以及脑代谢的变化。这篇综述综合了这些发现,强调了潜在的生物标志物和靶向治疗的意义。未来的研究应注重多模式、大样本量和纵向研究,以进一步阐明PPD的神经生物学基础,提高诊断和治疗水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroimaging biomarkers in postpartum depression: A comprehensive review of structural, functional, and metabolic alterations
Postpartum Depression (PPD) is a significant perinatal mood disorder affecting many new mothers in the first postpartum year. It is characterized by emotional, cognitive, and behavioral changes, often leading to delayed diagnosis due to nonspecific symptoms. PPD arises from a complex interplay of neuroendocrine, genetic, and psychosocial factors. Advances in neuroimaging have revealed structural, functional, and metabolic brain alterations associated with PPD. Specifically, structural MRI studies have shown gray matter volume changes in regions such as the dorsolateral prefrontal cortex and anterior insula, as well as white matter integrity changes in tracts like the internal capsule and cingulum. Functional MRI studies have revealed abnormal activity in regions including the amygdala, hippocampus, and prefrontal cortex, with altered functional connectivity within networks such as the default mode network. Metabolic studies using MRS and PET have identified imbalances in neurotransmitters like serotonin, glutamate, and GABA, as well as changes in brain metabolism.This review synthesizes these findings, highlighting potential biomarkers and implications for targeted treatments. Future research should focus on multimodal approaches, larger sample sizes, and longitudinal studies to further elucidate PPD's neurobiological basis and improve diagnosis and treatment.
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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