手性环己烷连接双咪唑啉的合成。

IF 2.1 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.140

Changmeng Xi, Qingshan Sun, Jiaxi Xu

引用次数: 0

摘要

手性双恶唑啉和双咪唑啉都是金属催化不对称有机转化的有效手性配体。以旋光性环己烷-1,2-二羧酸和1,2-二苯基乙烷-1,2-二胺为原料，经1,2-二苯基乙烷-1,2-二胺单磺化，n -磺化的1,2-二苯基乙烷-1,2-二胺和环己烷-1,2-二羧酸缩合，最后用原位生成的Hendrickson试剂环化制备手性环己烷-双咪唑啉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of chiral cyclohexane-linked bisimidazolines.

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Synthesis of chiral cyclohexane-linked bisimidazolines.

Both chiral bisoxazolines and bisimidazolines are efficient chiral ligands in metal-catalyzed asymmetric organic transformations. Chiral cyclohexane-linked bisimidazolines were prepared from optically active cyclohexane-1,2-dicarboxylic acid and 1,2-diphenylethane-1,2-diamines via the monosulfonylation of 1,2-diphenylethane-1,2-diamines, condensation of N-sulfonylated 1,2-diphenylethane-1,2-diamines and cyclohexane-1,2-dicarboxylic acid, and the final cyclization with the in situ generated Hendrickson reagent.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.