{"title":"硒化氢（H2Se）供体和前体的开发策略。","authors":"Jinxin Hu, Wenfang Liang, Long Yi","doi":"10.1002/asia.202500842","DOIUrl":null,"url":null,"abstract":"<p><p>Selenium (Se) is an essential trace element, and dietary Se sources can be metabolized to a shared metabolite, hydrogen selenide (H<sub>2</sub>Se). H<sub>2</sub>Se is the key precursor for the biosynthesis of Se-containing biomolecules and may be considered as an emerging gasotransmitter. Development of chemical tools and materials for controllable release of H<sub>2</sub>Se is significant in understanding Se-related chemical biology and may open new avenues for treating some diseases. In this review, we focus on the development of H<sub>2</sub>Se donors and precursors as well as their biological applications. In addition, we discuss the reaction mechanisms of these donors, the design strategies for fluorogenic donors, and future prospects of the H<sub>2</sub>Se field. We anticipate that this review would promote the development of advanced H<sub>2</sub>Se donors as potentially pharmacological research tools and help to further unearth the H<sub>2</sub>Se chemical biology.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00842"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Strategies for the Development of Donors and Precursors of Hydrogen Selenide (H<sub>2</sub>Se).\",\"authors\":\"Jinxin Hu, Wenfang Liang, Long Yi\",\"doi\":\"10.1002/asia.202500842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Selenium (Se) is an essential trace element, and dietary Se sources can be metabolized to a shared metabolite, hydrogen selenide (H<sub>2</sub>Se). H<sub>2</sub>Se is the key precursor for the biosynthesis of Se-containing biomolecules and may be considered as an emerging gasotransmitter. Development of chemical tools and materials for controllable release of H<sub>2</sub>Se is significant in understanding Se-related chemical biology and may open new avenues for treating some diseases. In this review, we focus on the development of H<sub>2</sub>Se donors and precursors as well as their biological applications. In addition, we discuss the reaction mechanisms of these donors, the design strategies for fluorogenic donors, and future prospects of the H<sub>2</sub>Se field. We anticipate that this review would promote the development of advanced H<sub>2</sub>Se donors as potentially pharmacological research tools and help to further unearth the H<sub>2</sub>Se chemical biology.</p>\",\"PeriodicalId\":145,\"journal\":{\"name\":\"Chemistry - An Asian Journal\",\"volume\":\" \",\"pages\":\"e00842\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry - An Asian Journal\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1002/asia.202500842\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1002/asia.202500842","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Strategies for the Development of Donors and Precursors of Hydrogen Selenide (H2Se).
Selenium (Se) is an essential trace element, and dietary Se sources can be metabolized to a shared metabolite, hydrogen selenide (H2Se). H2Se is the key precursor for the biosynthesis of Se-containing biomolecules and may be considered as an emerging gasotransmitter. Development of chemical tools and materials for controllable release of H2Se is significant in understanding Se-related chemical biology and may open new avenues for treating some diseases. In this review, we focus on the development of H2Se donors and precursors as well as their biological applications. In addition, we discuss the reaction mechanisms of these donors, the design strategies for fluorogenic donors, and future prospects of the H2Se field. We anticipate that this review would promote the development of advanced H2Se donors as potentially pharmacological research tools and help to further unearth the H2Se chemical biology.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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