{"title":"新型1-（5-苯基-1,3,4-恶二唑-2-基）甲基-3-（4-苯基噻唑-2-基）-1,8-萘啶-2(1H)- 1衍生物的合成及生物学评价","authors":"K. P. Kasaboina, K. Shireesha, K. S. Jella","doi":"10.1134/S1070363225602418","DOIUrl":null,"url":null,"abstract":"<p>A rapid and green synthesis of a novel 1-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1<i>H</i>)-one derivatives was proposed. The synthesized derivatives were evaluated for the biological evaluation of antibacterial and antifungal activity. All the assessed compounds exhibited promising antimicrobial activity, among all compounds 1-[5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1<i>H</i>)-one showing the strongest MIC values against <i>Staphylococcus aureus, S. epidermidis</i> (23, 23.5 μg/mL), <i>Escherichia coli, P. aeruginosa</i> (22.5, 26.5 μg/mL), <i>Candida albicans</i> (23.5 μg/mL), and <i>Candida metapsilosis</i> (24 μg/mL), <i>Aspergillus terreus</i> (25.5 μg/mL), <i>Aspergillus niger</i> (26 μg/mL), compared with the clinical reference drugs ampicillin and griseofulvin.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2081 - 2090"},"PeriodicalIF":0.8000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Biological Evaluation of Novel 1-(5-Phenyl-1,3,4-oxadiazol-2-yl)methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1H)-one Derivatives\",\"authors\":\"K. P. Kasaboina, K. Shireesha, K. S. Jella\",\"doi\":\"10.1134/S1070363225602418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A rapid and green synthesis of a novel 1-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1<i>H</i>)-one derivatives was proposed. The synthesized derivatives were evaluated for the biological evaluation of antibacterial and antifungal activity. All the assessed compounds exhibited promising antimicrobial activity, among all compounds 1-[5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1<i>H</i>)-one showing the strongest MIC values against <i>Staphylococcus aureus, S. epidermidis</i> (23, 23.5 μg/mL), <i>Escherichia coli, P. aeruginosa</i> (22.5, 26.5 μg/mL), <i>Candida albicans</i> (23.5 μg/mL), and <i>Candida metapsilosis</i> (24 μg/mL), <i>Aspergillus terreus</i> (25.5 μg/mL), <i>Aspergillus niger</i> (26 μg/mL), compared with the clinical reference drugs ampicillin and griseofulvin.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"95 8\",\"pages\":\"2081 - 2090\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070363225602418\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225602418","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and Biological Evaluation of Novel 1-(5-Phenyl-1,3,4-oxadiazol-2-yl)methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1H)-one Derivatives
A rapid and green synthesis of a novel 1-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1H)-one derivatives was proposed. The synthesized derivatives were evaluated for the biological evaluation of antibacterial and antifungal activity. All the assessed compounds exhibited promising antimicrobial activity, among all compounds 1-[5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl-3-(4-phenylthiazol-2-yl)-1,8-naphthyridin-2(1H)-one showing the strongest MIC values against Staphylococcus aureus, S. epidermidis (23, 23.5 μg/mL), Escherichia coli, P. aeruginosa (22.5, 26.5 μg/mL), Candida albicans (23.5 μg/mL), and Candida metapsilosis (24 μg/mL), Aspergillus terreus (25.5 μg/mL), Aspergillus niger (26 μg/mL), compared with the clinical reference drugs ampicillin and griseofulvin.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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