2-（五氟苯基）- 4h -铬-4- 1与烷基胺转化为抗菌和抗流感剂的研究

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225603497

K. V. Shcherbakov, K. A. Chernyakov, M. A. Panova, N. A. Gerasimova, N. P. Evstigneeva, A. S. Volobueva, M. A. Niukalova, V. V. Zarubaev, S. S. Borisevich, Ya. V. Burgart, V. I. Saloutin

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引用次数: 0

摘要

研究了2 ',3 ',4 ',5 ',6 ‘ -五氟黄酮与烷基胺的相互作用，在活化的C4 ’中心氟原子的区域选择性形成亲核芳香取代产物。对合成的黄酮进行生物活性评价，发现化合物具有较高的抗真菌、抗淋病和抗流感活性。分子对接表明，获得的黄酮对甲型H1N1流感病毒株A/Puerto Rico/8/34 （H1N1）的抑制机制可能与阻断神经氨酸酶有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Transformations of 2-(Pentafluorophenyl)-4H-chromen-4-one with Alkylamines into Antimicrobial and Anti-Influenza Agents

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Transformations of 2-(Pentafluorophenyl)-4H-chromen-4-one with Alkylamines into Antimicrobial and Anti-Influenza Agents

The interaction of 2′,3′,4′,5′,6′-pentafluoroflavone with alkylamines was studied, leading to the regioselective formation of nucleophilic aromatic substitution products of the fluorine atom at the activated C4′ center. Evaluation of the biological activity of the synthesized flavones revealed compounds with high antifungal, anti-gonorrheal, and anti-influenza activity. Molecular docking showed that the mechanism of influenza virus strain A/Puerto Rico/8/34 (H1N1) inhibition by the obtained flavones may be associated with neuraminidase blocking.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.