基于2-[3-烷基-5(morpholinomethyl)-4,5-二氢- 1h -吡唑-1-酰基]乙酰肼的1,3,4-恶二唑衍生物的合成

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225603412

A. R. Karayeva, M. I. Shatirova, G. M. Mamedova, Sh. K. Sheydayeva

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引用次数: 0

摘要

建立了以3,5-二取代吡唑啉酰肼为基础合成1,3,4-恶二唑-取代吡唑啉等融合含氮杂环化合物的有效方法。将合成的2-[3-甲基-5-（morpholinom甲基）吡唑啉]乙酰肼与乙酸和一氯乙酸氯酰化，得到N ' -乙酰基和N ' -氯乙酰基衍生物。在氯化磷的作用下，合成的吡唑啉衍生物的分子内环化提供了1,3,4-恶二唑取代吡唑啉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide

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Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide

An efficient method was developed for the synthesis of fused nitrogen-containing heterocyclic compounds, such as 1,3,4-oxadiazole-substituted pyrazolines based on 3,5-disubstituted pyrazoline acylhydrazide. N′-Acetyl- and N′-chloroacetyl derivatives were obtained by acylation of previously synthesized 2-[3-methyl-5-(morpholinomethyl)pyrazoline]acetohydrazide with acetic and monochloroacetic acids chlorides. Intramolecular cyclization of the synthesized pyrazoline derivatives under the action of phosphorus chloride furnished 1,3,4-oxadiazole-substituted pyrazolines.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.