水介导：2-氨基-6-[1,4-二氧基-3,4-二氢酞-2(1H)-基]-4-（1H-吲哚-3-基）- 4h -吡喃-3,5-二碳腈的高效合成

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225601577

K. Kalpana

引用次数: 0

摘要

以邻苯二甲酸、2-氰乙酰肼、1H-吲哚-3-醛和丙二腈为原料，以水为反应介质，一锅法合成了一系列新的2-氨基-6-（1,4-二氧基-3,4-二氢酞-2(1H)-基）-4-（1H-吲哚-3-基）-4-氨基-3,5-二腈衍生物。这种一锅四组分反应具有程序简单、对环境影响小、反应周期快、产率高等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Water Mediated: An Efficient Synthesis of 2-Amino-6-[1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl]-4-(1H-indol-3-yl)-4H-pyran-3,5-dicarbonitriles

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Water Mediated: An Efficient Synthesis of 2-Amino-6-[1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl]-4-(1H-indol-3-yl)-4H-pyran-3,5-dicarbonitriles

A novel series of 2-amino-6-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-4-(1H-indol-3-yl)-4Hpyran-3,5-dicarbonitrile derivatives were produced utilizing water as the reaction medium in a one-pot four-component synthesis with phthalic acid, 2-cyanoacetohydrazide, 1H-indole-3-carbaldehydes, and malononitrile. This one-pot four-component reaction offers the amazing advantages of a simple protocol, low environmental impact, rapid reaction periods, and high yields.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.