全息水凝胶绷带传感器持续监测伤口愈合†

IF 4.1 Q2 CHEMISTRY, ANALYTICAL
Yihan Zhang, Yubing Hu, Zhenkang Zhu, Yunuen Montelongo, Yanting Liu, Shihabuddeen Waqar, Yoon Soo Park, Leon CZ Chan, Nan Jiang and Ali K. Yetisen
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引用次数: 0

摘要

慢性伤口构成严重的健康和经济挑战。早期低钙(Ca2+)离子浓度通常表明感染。全息水凝胶传感器提供无标签传感平台,在肉眼或分光光度计可检测到的衍射波长变化时,提供实时和连续的分析物检测,提高了Ca2+离子浓度定量的可及性。在这里,我们提出了一种全息Ca2+离子绷带传感器,使用含羧酸的水凝胶在聚二甲基硅氧烷(PDMS)底物上,通过智能手机读数实时评估伤口愈合。通过仿真研究了机械强度对灵敏度的影响。全息Ca2+离子传感器在0-4 mmol L−1 Ca2+离子下重放35 nm(色调值变化7)的蓝移,在7分钟内从暗红色变为红色。在弯曲状态下,能准确、稳定(24小时以上)测量Ca2+离子。调整了PDMS的刚度以平衡舒适性和灵敏度。在护理点设置中,全息绷带传感器,包括全息水凝胶传感器,衬底层和深色棉花层,可以通过智能手机应用程序使用色调值连续监测Ca2+离子超过10小时。应用程序中的引导方框帮助用户在固有的20-33°狭窄视角范围内捕获图像。这种全息Ca2+离子绷带传感器通过智能手机读出的比色审讯促进个性化伤口评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Holographic hydrogel bandage sensor for continual monitoring of wound healing†

Holographic hydrogel bandage sensor for continual monitoring of wound healing†

Chronic wounds pose serious health and economic challenges. A low calcium (Ca2+) ion concentration during the early stage often indicates infections. Holographic hydrogel sensors offer label-free sensing platforms, providing real-time and continuous detections of analytes upon diffractive wavelength changes detectable by the naked eye or spectrophotometers, improving the Ca2+ ion concentration quantification accessibility. Herein, we present a holographic Ca2+ ion bandage sensor using carboxylate-containing hydrogels on polydimethylsiloxane (PDMS) substrates for real-time wound-healing assessment through smartphone readout. Simulations are conducted to investigate the effects of mechanical strength on sensitivity. The holographic Ca2+ ion sensor replays blueshifts of 35 nm (hue value change of 7) with 0–4 mmol L−1 Ca2+ ions, changing colors from dark red to red within 7 minutes. It can accurately and stably (over 24 hours) measure Ca2+ ions when bent. The stiffness of PDMS was tuned to balance comfort and sensitivity. In point-of-care settings, holographic bandage sensors, comprising the holographic hydrogel sensor, a backing layer, and a dark cotton layer, can continuously monitor Ca2+ ions over 10 hours via a smartphone application using hue values. A guiding square in the application assists users in capturing pictures within the inherently narrow viewing angle range of 20–33°. This holographic Ca2+ ion bandage sensor facilitates personalized wound assessment through colorimetric interrogation via smartphone readout.

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CiteScore
2.30
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