Kinga Joó , Lilla Csanádi , Ágnes Povázsai , Martin K. Nielsen
{"title":"评价在匈牙利种马场伊维菌素治疗后的疗效和圆形卵再现期","authors":"Kinga Joó , Lilla Csanádi , Ágnes Povázsai , Martin K. Nielsen","doi":"10.1016/j.vprsr.2025.101336","DOIUrl":null,"url":null,"abstract":"<div><div>Horses remain globally at constant risk of strongylid infections, with cyathostomins being particularly prevalent and abundant. It is essential to routinely monitor the efficacy of anthelmintics against equine nematodes. This study aimed to evaluate the efficacy of ivermectin against equine strongyles and estimate the strongyle egg reappearance period (ERP) following ivermectin treatment for the first time in Hungary. Fecal samples were collected from 57 Thoroughbred mares before treatment and at 2, 4, 5, 6, and 7 weeks post-treatment at a Hungarian National Stud Farm. Fecal egg counts (FECs) were determined using the Mini-FLOTAC technique. Fecal Egg Count Reduction (FECR) was calculated at two weeks post-treatment to evaluate efficacy using a Bayesian hierarchical model, and ERP was estimated following current guidelines. The FECR calculations did not indicate any evidence of resistance to ivermectin. Data suggested an ERP of 6 weeks, which is a notable reduction from historic data. Evaluation of two defined age groups suggested a longer ERP in the older group (12–20 years old). The decrease in ERP has emerged as a likely consequence of treatment-intensive deworming practices employed worldwide and represents a loss of anthelmintic performance. These findings underscore the need for implementing FEC-based management strategies in Hungary to preserve anthelmintic efficacy and reduce strongylid infection pressure on pastures.</div></div>","PeriodicalId":23600,"journal":{"name":"Veterinary parasitology, regional studies and reports","volume":"64 ","pages":"Article 101336"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating efficacy and strongyle egg reappearance period after ivermectin treatment in a Hungarian stud farm\",\"authors\":\"Kinga Joó , Lilla Csanádi , Ágnes Povázsai , Martin K. Nielsen\",\"doi\":\"10.1016/j.vprsr.2025.101336\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Horses remain globally at constant risk of strongylid infections, with cyathostomins being particularly prevalent and abundant. It is essential to routinely monitor the efficacy of anthelmintics against equine nematodes. This study aimed to evaluate the efficacy of ivermectin against equine strongyles and estimate the strongyle egg reappearance period (ERP) following ivermectin treatment for the first time in Hungary. Fecal samples were collected from 57 Thoroughbred mares before treatment and at 2, 4, 5, 6, and 7 weeks post-treatment at a Hungarian National Stud Farm. Fecal egg counts (FECs) were determined using the Mini-FLOTAC technique. Fecal Egg Count Reduction (FECR) was calculated at two weeks post-treatment to evaluate efficacy using a Bayesian hierarchical model, and ERP was estimated following current guidelines. The FECR calculations did not indicate any evidence of resistance to ivermectin. Data suggested an ERP of 6 weeks, which is a notable reduction from historic data. Evaluation of two defined age groups suggested a longer ERP in the older group (12–20 years old). The decrease in ERP has emerged as a likely consequence of treatment-intensive deworming practices employed worldwide and represents a loss of anthelmintic performance. These findings underscore the need for implementing FEC-based management strategies in Hungary to preserve anthelmintic efficacy and reduce strongylid infection pressure on pastures.</div></div>\",\"PeriodicalId\":23600,\"journal\":{\"name\":\"Veterinary parasitology, regional studies and reports\",\"volume\":\"64 \",\"pages\":\"Article 101336\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary parasitology, regional studies and reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405939025001443\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary parasitology, regional studies and reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405939025001443","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Evaluating efficacy and strongyle egg reappearance period after ivermectin treatment in a Hungarian stud farm
Horses remain globally at constant risk of strongylid infections, with cyathostomins being particularly prevalent and abundant. It is essential to routinely monitor the efficacy of anthelmintics against equine nematodes. This study aimed to evaluate the efficacy of ivermectin against equine strongyles and estimate the strongyle egg reappearance period (ERP) following ivermectin treatment for the first time in Hungary. Fecal samples were collected from 57 Thoroughbred mares before treatment and at 2, 4, 5, 6, and 7 weeks post-treatment at a Hungarian National Stud Farm. Fecal egg counts (FECs) were determined using the Mini-FLOTAC technique. Fecal Egg Count Reduction (FECR) was calculated at two weeks post-treatment to evaluate efficacy using a Bayesian hierarchical model, and ERP was estimated following current guidelines. The FECR calculations did not indicate any evidence of resistance to ivermectin. Data suggested an ERP of 6 weeks, which is a notable reduction from historic data. Evaluation of two defined age groups suggested a longer ERP in the older group (12–20 years old). The decrease in ERP has emerged as a likely consequence of treatment-intensive deworming practices employed worldwide and represents a loss of anthelmintic performance. These findings underscore the need for implementing FEC-based management strategies in Hungary to preserve anthelmintic efficacy and reduce strongylid infection pressure on pastures.
期刊介绍:
Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).