Prakruti S Rao,Senbagavalli Prakash Babu,Komala Ezhumalai,Selby Knudsen,Jayalakshmy Ramakrishnan,Noyal Joseph,Chelsie Cintron,Madolyn R Dauphinais,Prakash Babu Narasimhan,Padmini Salgame,Natasha S Hochberg,David L Hom,Scott K Heysell,Charles Robert Horsburgh,Jerrold J Ellner,Pranay Sinha,Sonali Sarkar
{"title":"印度孕妇和非孕妇结核病患者的利福平暴露","authors":"Prakruti S Rao,Senbagavalli Prakash Babu,Komala Ezhumalai,Selby Knudsen,Jayalakshmy Ramakrishnan,Noyal Joseph,Chelsie Cintron,Madolyn R Dauphinais,Prakash Babu Narasimhan,Padmini Salgame,Natasha S Hochberg,David L Hom,Scott K Heysell,Charles Robert Horsburgh,Jerrold J Ellner,Pranay Sinha,Sonali Sarkar","doi":"10.1093/infdis/jiaf467","DOIUrl":null,"url":null,"abstract":"This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and non-pregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rifampin Exposure in Pregnant and Non-Pregnant Women with Tuberculosis in India.\",\"authors\":\"Prakruti S Rao,Senbagavalli Prakash Babu,Komala Ezhumalai,Selby Knudsen,Jayalakshmy Ramakrishnan,Noyal Joseph,Chelsie Cintron,Madolyn R Dauphinais,Prakash Babu Narasimhan,Padmini Salgame,Natasha S Hochberg,David L Hom,Scott K Heysell,Charles Robert Horsburgh,Jerrold J Ellner,Pranay Sinha,Sonali Sarkar\",\"doi\":\"10.1093/infdis/jiaf467\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and non-pregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.\",\"PeriodicalId\":501010,\"journal\":{\"name\":\"The Journal of Infectious Diseases\",\"volume\":\"15 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiaf467\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiaf467","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rifampin Exposure in Pregnant and Non-Pregnant Women with Tuberculosis in India.
This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and non-pregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.
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