mRNA的粘膜和透皮递送策略：改变临床应用

IF 11.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2025-09-10 DOI:10.1016/j.jconrel.2025.114221

Lirong Wang , Hongzhang Deng

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引用次数: 0

摘要

由于信使RNA的独特性质，基于信使RNA （mRNA）的疗法在临床应用中显示出预防和治疗多种疾病的显着潜力。近年来，随着各种非侵入性策略的发展，mRNA的传递已经超越了传统的针头注射，旨在提高患者的依从性，降低感染风险，并消除注射相关的不适。其中，粘膜传递和透皮传递作为两种核心的无创策略，已成为推进mRNA临床翻译的关键方向。本文综述了现有的粘膜和透皮传递mRNA的策略，包括透皮、口服、肺部、鼻腔和阴道无创传递策略，重点介绍了每种策略的独特优势、面临的生理障碍及其最新研究进展。此外，我们还介绍了mRNA疗法目前在临床试验中的关键生物医学应用，例如针对传染病、癌症和心血管疾病的治疗。最后，我们对粘膜和透皮传递mRNA的剩余挑战和未来方向进行了展望。尽管存在这些障碍，我们相信推进这些策略对于改变临床实践和改善患者预后具有重大的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mucosal and transdermal delivery strategies for mRNA: Transforming the clinical applications

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Mucosal and transdermal delivery strategies for mRNA: Transforming the clinical applications

Messenger RNA (mRNA)-based therapies have demonstrated remarkable potential for the prevention and treatment of a wide range of diseases in clinical applications, owing to the unique properties of mRNA. In recent years, mRNA delivery has expanded beyond traditional needle-based injections, with the development of various non-invasive strategies aimed at enhancing patient compliance, reducing infection risks, and eliminating injection-related discomfort. Among them, mucosal delivery and transdermal delivery as two core non-invasive strategies, have become key directions for advancing the clinical translation of mRNA. In this review, we comprehensively summarize the existing mucosal and transdermal delivery mRNA delivery strategies, including transdermal, oral, pulmonary, nasal, and vaginal non-invasive delivery strategies, focusing on the unique advantages of each strategy, the physiological barriers it faces, and its latest research progress. Additionally, we present key biomedical applications of mRNA therapeutics currently in clinical trials, such as those targeting infectious diseases, cancers, and cardiovascular disorders. Finally, we offer a perspective on the remaining challenges and future directions for mucosal and transdermal delivery mRNA delivery. Despite these hurdles, we believe that advancing these strategies holds significant promise for transforming clinical practice and improving patient outcomes.

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.