EXPRESS: Effects of Magnesium and Potassium on Insulin Resistance and Blood Sugar Level among Insomniac Patients with Diabetes Mellitus-A Randomized Control Trial.

Aims: To compare the effect of magnesium and potassium on insulin resistance and blood sugar levels among insomniac patients with diabetes mellitus.

Methods: A randomized controlled study was conducted on 320 subjects enrolled in placebo (T1), Magnesium (T2), Potassium (T3) and Magnesium + Potassium (T4) treatment groups. Pre- and post-trial blood sugar and insulin levels were analyzed through blood. Insulin resistance was calculated by homeostatic model assessment for insulin resistance (HOMA-IR). Analysis was performed in IBM SPSS® version 25.0.

Results: HOMA-IR analysis showed that pre-treatment mean of T4 (Magnesium + Potassium group) was 3.01 ± 0.54, and post-treatment mean was 2.54 ± 0.29, showing significant reduction (p=0.001). There was significant association among post HOMA-IR score of treatment groups (p=0.001). Fasting blood sugar levels showed that all groups, except placebo, had significant differences in levels (p=0.001). A comparison between treatment groups concluded that blood sugar levels were associated with significant differences (p=0.001).

Conclusions: The study suggests that magnesium alone and magnesium coupled with potassium supplementation assist insomniac diabetics more effectively to regulate insulin resistance and increased blood sugar levels.