姜黄素对大鼠氧化应激、生化、分子和组织学紊乱的保护作用。

IF 2.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2025-09-06 DOI:10.1016/j.toxicon.2025.108567

Fatma M. El-Demerdash , Reda A. Soker , Hoda M. Nasr , Raghda A. El-Sayed , Wenyi Kang

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引用次数: 0

摘要

过度使用农药经常污染环境并造成健康风险。本研究旨在探讨姜黄素对苯甲酸埃维菌素毒性作用的潜在肝保护作用。采用6组雄性Wistar大鼠：对照组、姜黄素（Cur; 200 mg/kg）、苯甲酸埃马菌素低剂量（EMB-LD; 5 mg/kg BW）、苯甲酸埃马菌素高剂量（EMB-HD; 10 mg/kg BW）、Cur + EMB-LD、Cur + EMB-HD。大鼠口服剂量28天。结果表明，姜黄素具有较高的抗氧化活性，主要表现为DPPH、ABTS+清除能力和FRAP螯合能力。EMB-LD或EMB-HD可提高脂质过氧化和蛋白质氧化，并显著降低酶促和非酶促抗氧化剂。经EMB处理后，大鼠肝脏酶活性及血清脂质和蛋白质含量明显改变。此外，接受EMB的大鼠的促炎和凋亡相关基因和组织结构显著改变。然而，接受Cur的大鼠只增强了抗氧化状态，降低了氧化生物标志物。此外，与各自的治疗组相比，接受姜黄素然后被EMB陶醉的大鼠在大多数测量参数中表现出显著的调节。最后，用低剂量和高剂量的EMB治疗的大鼠都以剂量依赖的方式显示出明显的危险效应；然而，证实了其抗EMB肝毒性的强大作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hepatoprotection conferred by curcumin against emamectin benzoate-induced oxidative stress, biochemical, molecular, and histological disturbances in rats

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Hepatoprotection conferred by curcumin against emamectin benzoate-induced oxidative stress, biochemical, molecular, and histological disturbances in rats

Excessive use of pesticides frequently contaminates the environment and poses health risks. This study aimed to investigate the potential hepatoprotective effect of curcumin against the toxic effects of emamectin benzoate in rats. Six groups of male Wistar rats were used: control, curcumin (Cur; 200 mg/kg), Emamectin benzoate – low dose (EMB-LD; 5 mg/kg BW), Emamectin benzoate – high dose (EMB-HD; 10 mg/kg BW), Cur plus EMB-LD, and Cur plus EMB-HD, respectively. Rats received their doses orally for 28 days. Results revealed that curcumin possesses high antioxidant activity, as demonstrated by its DPPH, ABTS + scavenging activity, and FRAP chelating capacity. The administration of EMB-LD or EMB-HD elevated lipid peroxidation and protein oxidation and significantly decreased enzymatic and non-enzymatic antioxidants. Liver enzyme activities and lipid and protein contents in rat serum were markedly altered after EMB treatment. Additionally, pro-inflammatory and apoptosis-related genes, and tissue structure were significantly altered in rats that received EMB. However, rats receiving Cur only enhanced the antioxidant status and reduced oxidation biomarkers. Further, rats that received curcumin and then were intoxicated with EMB exhibited significant modulation in most measured parameters compared with their respective treated groups. Conclusively, rats treated with both low and high doses of EMB showed pronounced hazardous effects in a dose-dependent manner; however, Cur proved its powerful role against EMB hepatotoxicity.

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.