Giulia Brooks, Filippo Ghidini, Calogero Virgone, Federica De Corti
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引用次数: 0
摘要
近距离放射治疗已被用于儿童膀胱前列腺横纹肌肉瘤的多模式治疗在过去的二十年。本系统综述的目的是收集有关这一创新技术的当前证据，并特别关注其长期效果。方法：根据PRISMA标准，检索2000 - 2022年间发表的PubMed、Scopus和Web of Science论文。结果：检索得到7338篇论文，但只有7篇符合条件，共196名儿童，中位年龄为23至32个月，中位随访时间为8至64个月。5年总生存率优于90%。然而，66名儿童（35%）报告了至少一种涉及泌尿生殖器官的并发症。结论：近距离放射治疗在总生存率方面表现出积极的结果。另一方面，应进一步努力降低功能性泌尿生殖系统副作用的风险。
Long-term complications in patients with bladder-prostate rhabdomyosarcoma treated with brachytherapy: a systematic review.
Introduction: Brachytherapy has been used for the multimodal treatment of pediatric bladder-prostate rhabdomyosarcoma in the last two decades. The aim of this systematic review is to gather the current evidence about this innovative technique with a special focus on long-term outcomes.
Methods: According to PRISMA criteria, PubMed, Scopus, and Web of Science were searched for papers published between 2000 and 2022.
Results: The search yielded 7338 papers but only seven were eligible, for a total of 196 children with a median age ranging from 23 to 32 months and a median follow-up ranging from eight to 64 months. The five-year overall survival was superior to 90%. However, at least one complication involving the urogenital apparatus was reported in 66 children (35%).
Conclusion: Brachytherapy presented positive outcomes in terms of overall survival. On the other hand, further efforts should be made to decrease the risk of functional urogenital side effects.
期刊介绍：
Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children.
The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include:
-Review articles-
Original articles-
Technical innovations-
Letters to the editor
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