Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Marcony R Santhiago
{"title":"儿童角膜交联：系统回顾和未来展望。","authors":"Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Marcony R Santhiago","doi":"10.3928/1081597X-20250624-03","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To analyze stabilization results using various standard and accelerated corneal cross-linking (CXL) protocols in patients younger than 18 years.</p><p><strong>Methods: </strong>This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. A bibliographic search was carried out based on PubMed and Scopus data, with the last being performed in December 2024. Thirty-five articles were eligible for this review. To assess the effectiveness of CXL in children, maximum keratometry measurements were analyzed preoperatively and compared with postoperative values.</p><p><strong>Results: </strong>A total of 2,186 eyes were included in this review. This review consisted of 15 studies with the standard CXL protocol, 11 with the accelerated CXL protocol, and 9 comparative protocols. Standard and accelerated CXL protocols and comparative studies were analyzed separately. Most studies have shown stabilization rates greater than 80% with different CXL protocols. Factors such as younger age, severity of keratoconus, and cone eccentricity seem to influence the effectiveness of the procedure.</p><p><strong>Conclusions: </strong>The results indicate that standard and accelerated CXL are effective and safe therapeutic options for treating keratoconus in pediatric population.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"41 9","pages":"e1008-e1021"},"PeriodicalIF":3.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives.\",\"authors\":\"Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Marcony R Santhiago\",\"doi\":\"10.3928/1081597X-20250624-03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To analyze stabilization results using various standard and accelerated corneal cross-linking (CXL) protocols in patients younger than 18 years.</p><p><strong>Methods: </strong>This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. A bibliographic search was carried out based on PubMed and Scopus data, with the last being performed in December 2024. Thirty-five articles were eligible for this review. To assess the effectiveness of CXL in children, maximum keratometry measurements were analyzed preoperatively and compared with postoperative values.</p><p><strong>Results: </strong>A total of 2,186 eyes were included in this review. This review consisted of 15 studies with the standard CXL protocol, 11 with the accelerated CXL protocol, and 9 comparative protocols. Standard and accelerated CXL protocols and comparative studies were analyzed separately. Most studies have shown stabilization rates greater than 80% with different CXL protocols. Factors such as younger age, severity of keratoconus, and cone eccentricity seem to influence the effectiveness of the procedure.</p><p><strong>Conclusions: </strong>The results indicate that standard and accelerated CXL are effective and safe therapeutic options for treating keratoconus in pediatric population.</p>\",\"PeriodicalId\":16951,\"journal\":{\"name\":\"Journal of refractive surgery\",\"volume\":\"41 9\",\"pages\":\"e1008-e1021\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of refractive surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/1081597X-20250624-03\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/1081597X-20250624-03","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Corneal Cross-linking in Pediatric Populations: Systematic Review and Future Perspectives.
Purpose: To analyze stabilization results using various standard and accelerated corneal cross-linking (CXL) protocols in patients younger than 18 years.
Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. A bibliographic search was carried out based on PubMed and Scopus data, with the last being performed in December 2024. Thirty-five articles were eligible for this review. To assess the effectiveness of CXL in children, maximum keratometry measurements were analyzed preoperatively and compared with postoperative values.
Results: A total of 2,186 eyes were included in this review. This review consisted of 15 studies with the standard CXL protocol, 11 with the accelerated CXL protocol, and 9 comparative protocols. Standard and accelerated CXL protocols and comparative studies were analyzed separately. Most studies have shown stabilization rates greater than 80% with different CXL protocols. Factors such as younger age, severity of keratoconus, and cone eccentricity seem to influence the effectiveness of the procedure.
Conclusions: The results indicate that standard and accelerated CXL are effective and safe therapeutic options for treating keratoconus in pediatric population.
期刊介绍：
The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as:
• Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics”
• Supplemental videos and materials available for many articles
• Access to current articles, as well as several years of archived content
• Articles posted online just 2 months after acceptance.
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