有和没有covid -19后主观认知症状的个体的记忆和元记忆表现

IF 1.7 4区心理学 Q3 CLINICAL NEUROLOGY

Journal of clinical and experimental neuropsychology Pub Date : 2025-09-08 DOI:10.1080/13803395.2025.2555610

Breanna K Nelson, Edwina Picon, Lia Sayers, Lea N Farah, Sidney A Saint, Johnson Chen, Vesna Sossi, Mypinder S Sekhon, A Jon Stoessl, Cheryl Wellington, William G Honer, Donna Lang, William J Panenka, Noah D Silverberg

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引用次数: 0

摘要

背景：元记忆是对自身认知能力的认识和评价能力。这项研究考察了元记忆受损作为导致COVID-19后持续认知症状的可能机制。方法：招募既往患有COVID-19疾病的个体。参与者完成了关于身体健康、心理健康和COVID-19疾病的调查问卷。为了评估记忆和元记忆的表现，研究人员向参与者提供了50个单词，然后在每次试验后完成一个两种选择的强迫选择识别记忆任务，并对其进行信心评级。重复了3组，每组50次试验。应用信号检测理论框架推导内存性能（d‘）、元内存性能（meta-d’）和元内存效率（M-ratio）指标。我们比较了在进行元记忆评估时自我报告持续认知症状的参与者（n = 47）和否认持续认知症状的参与者（n = 87）。我们使用一般线性模型来比较各组，在COVID-19和记忆评估之间共变年龄和天数。结果：有和没有自我报告的持续性认知症状的参与者在记忆表现上没有差异(d': p =。24日,β= 0.22 95%可信区间[-0.1,0.6]),元记忆性能(meta-d”:p =。28, β = 0.20 95% CI[-0.2, 0.6])，或元记忆效率(M-ratio: p =。85, β = -0.04 95% ci[-0.4, 0.3])。持续认知症状的患者报告有较高程度的抑郁（p β = 0.83 95% CI[0.5, 1.2]）、焦虑（p β = 0.016, β = 0.50 95% CI[0.2, 0.9]）和躯体症状评分（p β = 0.92 95% CI[0.5, 1.3]）。结论：有和没有自我报告的持续性认知症状的患者具有相似的记忆准确性，并且都表现出良好的（同步的）记忆测试表现意识。虽然认知和元认知障碍似乎不太可能导致COVID-19后的认知症状，但心理困扰（尤其是焦虑）仍然是一个令人信服的潜在长期因素。未来的机制研究是必要的，以了解心理困扰是否以及如何导致认知症状，反之亦然。

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Memory and metamemory performance in individuals with and without post-COVID-19 subjective cognitive symptoms.

Background: Metamemory is the awareness of and ability to evaluate one's own cognitive abilities. This study examined impaired metamemory as a possible mechanism contributing to persistent cognitive symptoms after COVID-19.

Methods: Individuals with previous COVID-19 illness were recruited. Participants completed questionnaires regarding physical health, mental health, and their COVID-19 illness. To assess memory and metamemory performance, participants were presented with 50 words and then completed a two-alternative forced choice recognition memory task with a confidence rating after each trial. This was repeated for 3 blocks of 50 trials each. A signal detection theory framework was applied to derive metrics of memory performance (d'), metamemory performance (meta-d'), and metamemory efficiency (M-ratio). We compared participants who self-reported persistent cognitive symptoms at the time of their metamemory assessment (n = 47) to participants who denied persistent cognitive symptoms (n = 87). We used a general linear model to compare groups, covarying for age and days between COVID-19 and metamemory assessment.

Results: Participants with and without self-reported persistent cognitive symptoms did not differ on memory performance (d': p = .24, $β$ = 0.22 95% CI [-0.1, 0.6]), metamemory performance (meta-d': p = .28, $β$ = 0.20 95% CI [-0.2, 0.6]), or metamemory efficiency (M-ratio: p = .85, $β$ = -0.04 95% CI [-0.4, 0.3]). Those with persistent cognitive symptoms reported a higher degree of depression (p < 0.001, $β$ = 0.83 95% CI [0.5, 1.2]), anxiety (p = 0.016, $β$ = 0.50 95% CI [0.2, 0.9]), and somatic symptom scores (p < 0.001, $β$ = 0.92 95% CI [0.5, 1.3]).

Conclusions: Patients with and without self-reported persistent cognitive symptoms had similar memory accuracy and both demonstrated good (synchronous) awareness of their memory test performance. While both cognitive and metacognitive impairment appear unlikely to drive cognitive symptoms after COVID-19, psychological distress (particularly anxiety) remains a compelling candidate perpetuating factor. Future mechanistic research is necessary to understand if and how psychological distress contributes to cognitive symptoms, and vice versa.

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来源期刊

Journal of clinical and experimental neuropsychology 医学-临床神经学

CiteScore

3.20

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.