{"title":"中药天然产物：癌症治疗引起的心脏毒性的潜在治疗剂。","authors":"Ruoyu Jin, Qianhui You, Chenshi Li, Na Zhao, Chengyao Jia, Chinying Koo, Weiwei Zhang, Baonian Liu, Kaijian Huang","doi":"10.2147/DDDT.S545216","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer therapy-induced cardiotoxicity (CTIC) is a serious and increasingly recognized cause of death and disability among cancer survivors. It frequently necessitates the withdrawal or dose reduction of effective anticancer drugs, limiting therapeutic options and affecting patient outcomes. While CTIC poses a major health risk, the precise cellular and molecular mechanisms responsible for this toxicity remain elusive, which complicates the development of preventive and therapeutic strategies. In recent years, natural products derived from Traditional Chinese Medicine (TCM) have gained attention as potentially beneficial agents for CTIC management. These TCM natural products consist of biologically active compounds that often act on multiple therapeutic targets, offering a comprehensive approach to mitigating cardiotoxicity during cancer treatment. This review aims to provide a concise overview of CTIC associated with various anticancer drugs and examine the emerging research on TCM natural products in reducing the cardiotoxic effects related to cancer therapies, highlighting areas where further investigation is needed. In addition, we also provide the challenges and coping strategies faced by basic research and clinical transformation of Chinese medicine monomers.</p>","PeriodicalId":11290,"journal":{"name":"Drug Design, Development and Therapy","volume":"19 ","pages":"7653-7680"},"PeriodicalIF":5.1000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414463/pdf/","citationCount":"0","resultStr":"{\"title\":\"Natural Products From Traditional Chinese Medicine: Potential Therapeutic Agents in Cancer Therapy-Induced Cardiotoxicity.\",\"authors\":\"Ruoyu Jin, Qianhui You, Chenshi Li, Na Zhao, Chengyao Jia, Chinying Koo, Weiwei Zhang, Baonian Liu, Kaijian Huang\",\"doi\":\"10.2147/DDDT.S545216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer therapy-induced cardiotoxicity (CTIC) is a serious and increasingly recognized cause of death and disability among cancer survivors. It frequently necessitates the withdrawal or dose reduction of effective anticancer drugs, limiting therapeutic options and affecting patient outcomes. While CTIC poses a major health risk, the precise cellular and molecular mechanisms responsible for this toxicity remain elusive, which complicates the development of preventive and therapeutic strategies. In recent years, natural products derived from Traditional Chinese Medicine (TCM) have gained attention as potentially beneficial agents for CTIC management. These TCM natural products consist of biologically active compounds that often act on multiple therapeutic targets, offering a comprehensive approach to mitigating cardiotoxicity during cancer treatment. This review aims to provide a concise overview of CTIC associated with various anticancer drugs and examine the emerging research on TCM natural products in reducing the cardiotoxic effects related to cancer therapies, highlighting areas where further investigation is needed. In addition, we also provide the challenges and coping strategies faced by basic research and clinical transformation of Chinese medicine monomers.</p>\",\"PeriodicalId\":11290,\"journal\":{\"name\":\"Drug Design, Development and Therapy\",\"volume\":\"19 \",\"pages\":\"7653-7680\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414463/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Design, Development and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/DDDT.S545216\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Design, Development and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DDDT.S545216","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Natural Products From Traditional Chinese Medicine: Potential Therapeutic Agents in Cancer Therapy-Induced Cardiotoxicity.
Cancer therapy-induced cardiotoxicity (CTIC) is a serious and increasingly recognized cause of death and disability among cancer survivors. It frequently necessitates the withdrawal or dose reduction of effective anticancer drugs, limiting therapeutic options and affecting patient outcomes. While CTIC poses a major health risk, the precise cellular and molecular mechanisms responsible for this toxicity remain elusive, which complicates the development of preventive and therapeutic strategies. In recent years, natural products derived from Traditional Chinese Medicine (TCM) have gained attention as potentially beneficial agents for CTIC management. These TCM natural products consist of biologically active compounds that often act on multiple therapeutic targets, offering a comprehensive approach to mitigating cardiotoxicity during cancer treatment. This review aims to provide a concise overview of CTIC associated with various anticancer drugs and examine the emerging research on TCM natural products in reducing the cardiotoxic effects related to cancer therapies, highlighting areas where further investigation is needed. In addition, we also provide the challenges and coping strategies faced by basic research and clinical transformation of Chinese medicine monomers.
期刊介绍：
Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications.
The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas.
Specific topics covered by the journal include:
Drug target identification and validation
Phenotypic screening and target deconvolution
Biochemical analyses of drug targets and their pathways
New methods or relevant applications in molecular/drug design and computer-aided drug discovery*
Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes)
Structural or molecular biological studies elucidating molecular recognition processes
Fragment-based drug discovery
Pharmaceutical/red biotechnology
Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products**
Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development
Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing)
Preclinical development studies
Translational animal models
Mechanisms of action and signalling pathways
Toxicology
Gene therapy, cell therapy and immunotherapy
Personalized medicine and pharmacogenomics
Clinical drug evaluation
Patient safety and sustained use of medicines.
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